Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2) Antibody from ABBEXA LTD
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| Antigenic Specificity | Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. |
| Immunogen | KLH-conjugated synthetic peptide between 1151-1179 amino acids from the C-terminal region of human ERBB2. |
| Other Names | C-erbB-2, Epidermal growth factor receptor-related protein, ErbB2, HER2, MLN 19, NEU, NEU proto-oncogene, NGL, Receptor protein-tyrosine kinase erbB-2, Receptor protein-tyrosine kinase erbB-2 precursor, Tyrosine kinase-type cell surface receptor HER2, kinase ErbB2, p185erbB2, Epidermal Growth Factor Receptor 2, EGFR2, CD340 Antigen, HER-2/Neu, Herstatin, CD340, HER-2, MLN19, TKR1, C-Erb B2/Neu Protein, HER 2, erbb2, Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Kiaa3023, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian), human epidermal growth factor receptor 2, C-erbB-2, C-erbB-2, C-erbB-2 , C-erbB-2 , Epidermal growth factor receptor-related protein, Epidermal growth factor receptor-related protein, Epidermal growth factor receptor-related protein , Epidermal growth factor receptor-related protein , ErbB2, ErbB2, ErbB2 , ErbB2 , HER2, HER2, H |
| Gene, Accession # | NCBI: NP_001005862.1, NP_004439.2, UniProt: P04626 |
| Catalog # | abx030629 |
| Price | please inquire |
| Order / More Info | Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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