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Antigenic Specificity | TYRO Protein Tyrosine Kinase Binding Protein (TYROBP) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 80 µl, 400 µl, |
Concentration | n/a |
Applications | ELISA, WB, IHC, FCM |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | TYROBP encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. |
Immunogen | KLH-conjugated synthetic peptide between 85-113 amino acids from the C-terminal region of human TYROBP. |
Other Names | TYROBP, TYRO Protein Tyrosine Kinase Binding Protein, DNAX-Activation Protein 12, Killer-Activating Receptor-Associated Protein, TYRO Protein Tyrosine Kinase-Binding Protein, KAR-Associated Protein, DAP12, KARAP, Killer Activating Receptor Associated Protein, PLOSL1, PLOSL, TYROBP, TYROBP, TYROBP , TYROBP , TYRO Protein Tyrosine Kinase Binding Protein, TYRO Protein Tyrosine Kinase Binding Protein, TYRO Protein Tyrosine Kinase Binding Protein , TYRO Protein Tyrosine Kinase Binding Protein , DNAX-Activation Protein 12, DNAX-Activation Protein 12, DNAX-Activation Protein 12 , DNAX-Activation Protein 12 , Killer-Activating Receptor-Associated Protein, Killer-Activating Receptor-Associated Protein, Killer-Activating Receptor-Associated Protein , Killer-Activating Receptor-Associated Protein , TYRO Protein Tyrosine Kinase-Binding Protein, TYRO Protein Tyrosine Kinase-Binding Protein, TYRO Protein Tyrosine Kinase-Binding Protein , TYRO Protein Tyrosine Kinase-Binding Protein , KAR-Associ |
Gene, Accession # | TYROBP, UniProt: O43914 |
Catalog # | abx034547 |
Price | please inquire |
Order / More Info | TYRO Protein Tyrosine Kinase Binding Protein (TYROBP) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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