TNFA/TNF alpha (Golimumab biosimilar) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-TNFA/TNF alpha (Golimumab biosimilar) antibody, protein, ELISA kits.
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| Antigenic Specificity | TNFA/TNF alpha (Golimumab biosimilar) |
| Clone | monoclonal |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 kappa |
| Format | Protein A/G purified |
| Size | 100 µg, 1 mg, |
| Concentration | typically between 0.5-2.0 mg/ml. |
| Applications | ELISA, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Golimumab is a monoclonal antibody biosimilar expressed in CHO cells, targeting TNFA/TNF alpha, for use in laboratory research applications. This product is not suitable for use as medicines or in human, therapeutic or diagnostic applications. Golimumab is a human IgG1? monoclonal antibody derived from immunizing genetically engineered mice with human TNF?. Golimumab binds and inhibits soluble and transmembrane human TNF?. Increased TNF? is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate treatment in patients with moderate to severe active rheumatoid arthritis (RA), (ii) alone or as an adjunct to methotrexate treatment in patients with active psoriatic arthritis (PsA), (iii) as a single agent in patients with active ankylosing spondylitis (AS), and (iv) as a single agent in patients with moderate to severe ulcerative colitis (UC) who require chronic steroids or have experienced intolerance or only a partial response to previous medications. In the U. S. and Canada, golimumab is marketed under the brand name Simponi®. The FDA label includes a black box warning of serious infections and malignancy. Additionally in children and adolescents taking golimumab, there have been lymphoma and other malignancies observed. As a human monoclonal antibody, golimumab binds and inhibits soluble and transmembrane human TNF?. Inhibition of TNF? prevents it binding to its receptors, which prevents both leukocyte infiltration through prevention of cell adhesion proteins such as E-selectin, ICAM-1 and VCAM-1, and pro-inflammatory cytokine secretion such as IL-6, IL-8, G-CSF and GM-CSF in vitro. Consequently, in patients with chronic inflammatory conditions, decreases in ICAM-1 and IL-6 as well as C-reactive protein (CRP), matrix metalloproteinase 3 (MMP-3), and vascular endothelial growth factor (VEGF) were observed. |
| Immunogen | n/a |
| Other Names | Golimumab, TNFA/TNF alpha, 476181-74-5 |
| Gene, Accession # | CAS: 476181-74-5 |
| Catalog # | abx831088 |
| Price | please inquire |
| Order / More Info | TNFA/TNF alpha (Golimumab biosimilar) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
ABBEXA LTD
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Cambridge, CB4 0GJ UK
P: +44 (0) 1223 755950
Customer Service: info@abbexa.com
Technical Support: support@abbexa.com
Orders: orders@abbexa.com
https://www.abbexa.com
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Telephone: +44 (0) 1223 755950
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