Tyrosine-Protein Kinase ITK/TSK (ITK) Antibody from ABBEXA LTD
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| Antigenic Specificity | Tyrosine-Protein Kinase ITK/TSK (ITK) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 100 µg, |
| Concentration | 2 mg/ml |
| Applications | ELISA, WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Tyrosine-Protein Kinase ITK/TSK (ITK) antibody is a Rabbit polyclonal antibody for the detection of ITK. Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. |
| Immunogen | IL2-inducible T-cell kinase |
| Other Names | ITK, IL2 Inducible T-Cell Kinase, IL-2-Inducible T-Cell Kinase, PSCTK2, EMT, Kinase EMT, LYK, T-Cell-Specific Kinase, Tyrosine-protein kinase Lyk, Interleukin-2-Inducible T-Cell Kinase, Tyrosine-Protein Kinase ITK/TSK, Homolog Of Mouse T-Cell Itk/Tsk, EC 2.7.10.2, EC 2.7.10, LPFS1, ITK/TSK, TLK, TSK, Kinase LTK, MGC126257, MGC126258, ITK, ITK, ITK , ITK , IL2 Inducible T-Cell Kinase, IL2 Inducible T-Cell Kinase, IL2 Inducible T-Cell Kinase , IL2 Inducible T-Cell Kinase , IL-2-Inducible T-Cell Kinase, IL-2-Inducible T-Cell Kinase, IL-2-Inducible T-Cell Kinase , IL-2-Inducible T-Cell Kinase , PSCTK2, PSCTK2, PSCTK2 , PSCTK2 , EMT, EMT, EMT , EMT , Kinase EMT, Kinase EMT, Kinase EMT , Kinase EMT , LYK, LYK, LYK , LYK , T-Cell-Specific Kinase, T-Cell-Specific Kinase, T-Cell-Specific Kinase , T-Cell-Specific Kinase , Tyrosine-protein kinase Lyk, Tyrosine-protein kinase Lyk, Tyrosine-protein kinase Lyk , Tyrosine-protein kinase Lyk , Interleukin-2-Inducible T-Cell Kinase, Interleuk |
| Gene, Accession # | ITK, Gene ID: 3702, UniProt: Q08881 |
| Catalog # | abx240182 |
| Price | please inquire |
| Order / More Info | Tyrosine-Protein Kinase ITK/TSK (ITK) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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