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Antigenic Specificity | HLA Class II Histocompatibility Antigen, DQ Alpha 1 Chain (HLA-DQA1) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 80 µl, 400 µl, |
Concentration | n/a |
Applications | ELISA, WB, FCM |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. |
Immunogen | KLH-conjugated synthetic peptide between 39-66 amino acids from the N-terminal region of human HLA-DQA1. |
Other Names | DC-1 alpha chain, DC-alpha, HLA-DCA, MHC class II DQA1, Mhc Class Ii Dqa1Hla Class Ii Histocompatibility Antigen, Dq Alpha 1 Chain, HLA class II histocompatibility antigen, HLA-DQA1, CD, CELIAC1, DQ-A1, GSE, HLA-DQA, DC-1 alpha chain, DC-1 alpha chain, DC-1 alpha chain , DC-1 alpha chain , DC-alpha, DC-alpha, DC-alpha , DC-alpha , HLA-DCA, HLA-DCA, HLA-DCA , HLA-DCA , MHC class II DQA1, MHC class II DQA1, MHC class II DQA1 , MHC class II DQA1 , Mhc Class Ii Dqa1Hla Class Ii Histocompatibility Antigen, Mhc Class Ii Dqa1Hla Class Ii Histocompatibility Antigen, Mhc Class Ii Dqa1Hla Class Ii Histocompatibility Antigen , Mhc Class Ii Dqa1Hla Class Ii Histocompatibility Antigen , Dq Alpha 1 Chain, Dq Alpha 1 Chain, Dq Alpha 1 Chain , Dq Alpha 1 Chain , HLA class II histocompatibility antigen, HLA class II histocompatibility antigen, HLA class II histocompatibility antigen , HLA class II histocompatibility antigen , HLA-DQA1, HLA-DQA1, HLA-DQA1 , HLA-DQA1 , CD, CD, CD , CD , CELIAC1, |
Gene, Accession # | HLA-DQA1, UniProt: P01909 |
Catalog # | abx025082 |
Price | please inquire |
Order / More Info | HLA Class II Histocompatibility Antigen, DQ Alpha 1 Chain (HLA-DQA1) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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