Mitogen-Activated Protein Kinase 7 / ERK5 (MAPK7) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-Mitogen-Activated Protein Kinase 7 / ERK5 (MAPK7) antibody, protein, ELISA kits.
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| Antigenic Specificity | Mitogen-Activated Protein Kinase 7 / ERK5 (MAPK7) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 20 µl, 50 µl, 100 µl, 200 µl |
| Concentration | > 0.5 mg/ml |
| Applications | WB, IHC, IF/ICC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | MAPK7 antibody is a Rabbit polyclonal antibody against MAPK7. ERK5 (Mitogen-activated protein kinase 7, Big mitogen-activated protein kinase 1) is a member of the MAPK superfamily implicated in the regulation numerous cellular processes including proliferation, differentiation, and survival (1,5-7). Like other MAPK family members, ERK5 contains a canonical activation loop TEY motif (Thr218/Tyr220) which is specifically phosphorylated by MAP2K5 (MEK5) in a growth factor-dependent, Ras-independent mechanism (2-4). For example, EGF stimulation promotes ERK5 phosphorylation which induces its traslocation to the nucleus where it phosphorylates MEF2C and other transcriptional targets (2,3). ERK5 is also activated in response to granulocyte colony-stimulating factor (G-CSF) in hematopoetic progenitor cells where it promotes survival and proliferation (4). In neuronal cells, ERK5 is required for NGF-induced neurite outgrowth, neuronal homeostatis, and survival (11,12). ERK5 is thought to play a role in blood vessel integrity via maintainence of endothelial cell migration and barrier function (8-10). Although broadly expressed, research studies have shown that mice lacking erk5 display numerous cardiac defects, suggesting ERK5 plays a critical role in vascular development and homeostasis (1,5). |
| Immunogen | Recombinant protein of human MAPK7. |
| Other Names | Big MAP kinase 1, BMK 1, BMK 1 kinase, BMK-1, BMK1, BMK1 Kinase, ERK 4, ERK 5, ERK-5, ERK4, ERK5, Extracellular Signal Regulated Kinase 5, Extracellular signal-regulated kinase 5, MAP kinase 7, MAPK 7, MAPK7, Mitogen Activated Protein Kinase 7, Mitogen-activated protein kinase 7, OTTHUMP00000065906, OTTHUMP00000065907, PRKM 7, PRKM7, PROTEIN KINASE, MITOGEN-ACTIVATED, Big MAP kinase 1, Big MAP kinase 1, Big MAP kinase 1 , Big MAP kinase 1 , BMK 1, BMK 1, BMK 1 , BMK 1 , BMK 1 kinase, BMK 1 kinase, BMK 1 kinase , BMK 1 kinase , BMK-1, BMK-1, BMK-1 , BMK-1 , BMK1, BMK1, BMK1 , BMK1 , BMK1 Kinase, BMK1 Kinase, BMK1 Kinase , BMK1 Kinase , ERK 4, ERK 4, ERK 4 , ERK 4 , ERK 5, ERK 5, ERK 5 , ERK 5 , ERK-5, ERK-5, ERK-5 , ERK-5 , ERK4, ERK4, ERK4 , ERK4 , ERK5, ERK5, ERK5 , ERK5 , Extracellular Signal Regulated Kinase 5, Extracellular Signal Regulated Kinase 5, Extracellular Signal Regulated Kinase 5 , Extracellular Signal Regulated Kinase 5 , Extracellular signal-regulated kinase |
| Gene, Accession # | MAPK7, Gene ID: 5598, UniProt: Q13164 |
| Catalog # | abx001723 |
| Price | please inquire |
| Order / More Info | Mitogen-Activated Protein Kinase 7 / ERK5 (MAPK7) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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