T-lymphocyte activation antigen CD80 / B7-1 (CD80) Antibody from ABBEXA LTD
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| Antigenic Specificity | T-lymphocyte activation antigen CD80 / B7-1 (CD80) |
| Clone | monoclonal |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | ascites |
| Size | 100 µl, |
| Concentration | n/a |
| Applications | ELISA, IHC, IF/ICC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The protein CD80 (Cluster of Differentiation 80) is a molecule found on activated B cells and monocytes which provides a costimulatory signal necessary for T cell activation and survival.It is also known as B7.1.Its principal mode of action is by binding to CD28.Along with CD86, these molecules provide the necessary stimuli to prime T cells against antigens presented by antigen-presenting cells.CD80 and CD86 also bind to CTLA-4, a cell surface molecule expressed on activated T cells.Interactions between CD80 or CD86 with CTLA-4 decrease the response of T cells.Mouse research by scientists at Emory University showed that estrogen-related bone loss is linked to recently discovered pathways involving various proteins, such as CD80 and other functions.In a nutshell, reactive oxygen stimulates dendritic cells, which activate other immune cells to up-regulate production of CD80, the molecule co-responsible for T cell activation.""When this pathway is activated, it leads to increased T cell TNF production and ultimately to bone loss."" In turn, T cells produce a protein, Tumor Necrosis Factor, which increases the formation of osteoclasts in rodents and humans.Osteoclasts cause minerals to be released from the bone, so that calcium is taken into the bloodstream to be used for other functions of the body.Osteoclast differentiation is inhibited by osteoprotegerin; Estrogen stimulates osteoprotegerin production. |
| Immunogen | Purified recombinant fragment of CD80 expressed in E. coli. |
| Other Names | CD28LG, CD28LG1, LAB7, T-lymphocyte activation antigen CD80, Activation B7-1 antigen, BB1, CTLA-4 counter-receptor B7.1, B7, CD antigen CD80, B7.1, CD80, B7-1, CD80 antigen, CD80 molecule, B-lymphocyte activation antigen B7, CD80 antigen (CD28 antigen ligand 1, B7-1 antigen), costimulatory factor CD80, costimulatory molecule variant IgV-CD80, MAb to CD80, CD28LG, CD28LG, CD28LG , CD28LG , CD28LG1, CD28LG1, CD28LG1 , CD28LG1 , LAB7, LAB7, LAB7 , LAB7 , T-lymphocyte activation antigen CD80, T-lymphocyte activation antigen CD80, T-lymphocyte activation antigen CD80 , T-lymphocyte activation antigen CD80 , Activation B7-1 antigen, Activation B7-1 antigen, Activation B7-1 antigen , Activation B7-1 antigen , BB1, BB1, BB1 , BB1 , CTLA-4 counter-receptor B7.1, CTLA-4 counter-receptor B7.1, CTLA-4 counter-receptor B7.1 , CTLA-4 counter-receptor B7.1 , B7, B7, B7 , B7 , CD antigen CD80, CD antigen CD80, CD antigen CD80 , CD antigen CD80 , B7.1, B7.1, B7.1 , B7.1 , CD80, CD80, CD80 , |
| Gene, Accession # | Gene ID: 941, 12519, 100009377 |
| Catalog # | abx015727 |
| Price | please inquire |
| Order / More Info | T-lymphocyte activation antigen CD80 / B7-1 (CD80) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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