Forkhead Box Protein O3 (FOXO3A) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-Forkhead Box Protein O3 (FOXO3A) antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | Forkhead Box Protein O3 (FOXO3A) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 100 µg, |
| Concentration | 2 mg/ml |
| Applications | ELISA, WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Forkhead Box Protein O3 (FOXO3A) antibody is a Rabbit polyclonal antibody for the detection of FOXO3A. Forkhead box O-class (FOXO) transcription factors are mammalian homologue of DAF-16, a known lifespan regulator of Caenorhabditis elegans. FOXO transcription factors, such as FOXO1, FOXO3a, and FOXO4, have been linked to the regulation of cell cycle, apoptosis, DNA repair, oxidative stress, and metabolism. FOXO proteins are proposed to be dual regulated by Akt-mediated phosphorylation and Skp2-mediated ubiquitination, which are usually initiated by growth factors and cytokines. FOXO proteins are also activated by stress, which induces gene expression that contributes to cell cycle arrest, implicating FOXO proteins as tumor suppressors. Specifically, FOXO3a (FKHR-L1) is a transcriptional activator for apoptosis in the absence of survival factors, such as in neural cell death triggered by oxidative stress. In the presence of survival factors like IGF-1, AKT1/PKB phosphorylates on Thr-32 and Ser-253. FOXO3a is inactivated when phosphorylated by AKT1 on Thr-32 and Ser-253. |
| Immunogen | forkhead box O3 |
| Other Names | FOXO3, FOXO3A, FKHRL1, AF6q21, FKHRL1P2, MGC12739, MGC31925, DKFZp781A0677, forkhead box O3A, forkhead (Drosophila) homolog, FOXO2, forkhead homolog (rhabdomyosarcoma) like 1, forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1 (rhabdomyosarcoma), FOXO3, FOXO3, FOXO3 , FOXO3 , FOXO3A, FOXO3A, FOXO3A , FOXO3A , FKHRL1, FKHRL1, FKHRL1 , FKHRL1 , AF6q21, AF6q21, AF6q21 , AF6q21 , FKHRL1P2, FKHRL1P2, FKHRL1P2 , FKHRL1P2 , MGC12739, MGC12739, MGC12739 , MGC12739 , MGC31925, MGC31925, MGC31925 , MGC31925 , DKFZp781A0677, DKFZp781A0677, DKFZp781A0677 , DKFZp781A0677 , forkhead box O3A, forkhead box O3A, forkhead box O3A , forkhead box O3A , forkhead (Drosophila) homolog, forkhead (Drosophila) homolog, forkhead (Drosophila) homolog , forkhead (Drosophila) homolog , FOXO2, FOXO2, FOXO2 , FOXO2 , forkhead homolog (rhabdomyosarcoma) like 1, forkhead homolog (rhabdomyosarcoma) like 1, forkhead homolog (rhabdomyosarcoma) like 1 , forkhead homolog (rhabdomyosarcoma) like 1 , for |
| Gene, Accession # | FOXO3, Gene ID: 2309, UniProt: O43524 |
| Catalog # | abx011937 |
| Price | please inquire |
| Order / More Info | Forkhead Box Protein O3 (FOXO3A) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
ABBEXA LTD
181 Cambridge Science Park
Cambridge, CB4 0GJ UK
P: +44 (0) 1223 755950
Customer Service: info@abbexa.com
Technical Support: support@abbexa.com
Orders: orders@abbexa.com
https://www.abbexa.com
U.S. Office
118 Eldridge Rd, Suite C,
Sugar Land, TX 77478 USA
Telephone: +1 832 327 7413
Netherlands Office
Abbexa BV
Wattstraat 54 2723 RD,
Zoetermeer,Netherlands
Telephone: +44 (0) 1223 755950
Profile of ABBEXA LTD
Return to Antibodies