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Antigenic Specificity | TYRO Protein Tyrosine Kinase Binding Protein (TYROBP) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 20 µl, 50 µl, 100 µl, 200 µl |
Concentration | > 0.5 mg/ml |
Applications | IHC |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | TYROBP Antibody is a Rabbit Polyclonal antibody against TYROBP. This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. |
Immunogen | Recombinant protein of human TYROBP. |
Other Names | TYROBP, TYRO Protein Tyrosine Kinase Binding Protein, DNAX-Activation Protein 12, Killer-Activating Receptor-Associated Protein, TYRO Protein Tyrosine Kinase-Binding Protein, KAR-Associated Protein, DAP12, KARAP, Killer Activating Receptor Associated Protein, PLOSL1, PLOSL, TYROBP, TYROBP, TYROBP, TYROBP, TYRO Protein Tyrosine Kinase Binding Protein, TYRO Protein Tyrosine Kinase Binding Protein, TYRO Protein Tyrosine Kinase Binding Protein, TYRO Protein Tyrosine Kinase Binding Protein, DNAX-Activation Protein 12, DNAX-Activation Protein 12, DNAX-Activation Protein 12, DNAX-Activation Protein 12, Killer-Activating Receptor-Associated Protein, Killer-Activating Receptor-Associated Protein, Killer-Activating Receptor-Associated Protein, Killer-Activating Receptor-Associated Protein, TYRO Protein Tyrosine Kinase-Binding Protein, TYRO Protein Tyrosine Kinase-Binding Protein, TYRO Protein Tyrosine Kinase-Binding Protein, TYRO Protein Tyrosine Kinase-Binding Protein, KAR-Associated Protein, KAR-Associated Protein, KAR-Associated Protein, KAR-Associated Protein, DAP12, DAP12, DAP12, DAP12, KARAP, KARAP, KARAP, KARAP, Killer Activating Receptor Associated Protein, Killer Activating Receptor Associated Protein, Killer Activating Receptor Associated Protein, Killer Activating Receptor Associated Protein, PLOSL1, PLOSL1, PLOSL1, PLOSL1, PLOSL, PLOSL, PLOSL, PLOSL |
Gene, Accession # | TYROBP, Gene ID: 7305, UniProt: O43914 |
Catalog # | abx004123 |
Price | please inquire |
Order / More Info | TYRO Protein Tyrosine Kinase Binding Protein (TYROBP) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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