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Antigenic Specificity | 14-3-3 Protein Sigma (SFN) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 20 µl, 50 µl, 100 µl, 200 µl |
Concentration | > 0.5 mg/ml |
Applications | WB, IHC, IF/ICC |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | SFN antibody is a Rabbit polyclonal antibody against SFN. 14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms, denoted 14-3-3 b, g, e, z, h, q and s, comprise this family of signaling intermediates. 14-3-3 s, also known as SFN, stratifin, HME1 or YWHAS, is a secreted adaptor protein that is involved in regulating both general and specific signaling pathways. Expressed predominately in stratified squamous keratinising epithelium, 14-3-3 s is able to bind and modify the activity of a large number of proteins, such as KRT17 (Keratin 17), through recognition of a phosphothreonine or phosphoserine motif. When bound to Keratin 17, for example, 14-3-3 s acts to stimulate the Akt/mTOR signaling pathway by upregulating protein synthesis and cell growth. 14-3-3 s also functions to positively mediate IGF-I-induced cell cycle progression and can bind to a variety of translation initiation factors, thus controlling mitotic translation. In response to tumor growth, 14-3-3 s positively regulates the tumor suppressor p53 and increases the rate of p53-regulated inhibition of G2/M cell cycle progression. Multiple isoforms of 14-3-3 s exist due to alternative splicing events. |
Immunogen | Recombinant protein of human SFN. |
Other Names | SFN, HME1, 14-3-3 protein sigma, Epithelial cell marker protein 1, Stratifin, YWHAS, SFN, SFN, SFN , SFN , HME1, HME1, HME1 , HME1 , 14-3-3 protein sigma, 14-3-3 protein sigma, 14-3-3 protein sigma , 14-3-3 protein sigma , Epithelial cell marker protein 1, Epithelial cell marker protein 1, Epithelial cell marker protein 1 , Epithelial cell marker protein 1 , Stratifin, Stratifin, Stratifin , Stratifin , YWHAS, YWHAS, YWHAS , YWHAS |
Gene, Accession # | SFN, Gene ID: 2810, UniProt: P31947 |
Catalog # | abx000967 |
Price | please inquire |
Order / More Info | 14-3-3 Protein Sigma (SFN) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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