H/ACA Ribonucleoprotein Complex Subunit DKC1 (DKC1) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-H/ACA Ribonucleoprotein Complex Subunit DKC1 (DKC1) antibody, protein, ELISA kits.
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| Antigenic Specificity | H/ACA Ribonucleoprotein Complex Subunit DKC1 (DKC1) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 20 µl, 50 µl, 100 µl, 200 µl |
| Concentration | > 0.5 mg/ml |
| Applications | WB, IHC, IF/ICC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | DKC1 antibody is a Rabbit polyclonal antibody against DKC1. This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the NOLA1, 2 and 3 proteins. The protein encoded by this gene and the three NOLA proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The protein encoded by this gene is related to the Saccharomyces cerevisiae Cbf5p and Drosophila melanogaster Nop60B proteins. The gene lies in a tail-to-tail orientation with the palmitoylated erythrocyte membrane protein gene and is transcribed in a telomere to centromere direction. Both nucleotide substitutions and single trinucleotide repeat polymorphisms have been found in this gene. Mutations in this gene cause X-linked dyskeratosis congenita, a disease resulting in reticulate skin pigmentation, mucosal leukoplakia, nail dystrophy, and progressive bone marrow failure in most cases. Mutations in this gene also cause Hoyeraal-Hreidarsson syndrome, which is a more severe form of dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]. |
| Immunogen | Recombinant protein of human DKC1. |
| Other Names | DKC1, DKC, CBF5, DKCX, NAP57, NOLA4, XAP101, dyskeratosis congenita 1, dyskerin, H/ACA ribonucleoprotein complex subunit 4, CBF5 homolog, Dyskerin, Nopp140-associated protein of 57 kDa, Nucleolar protein NAP57, Nucleolar protein family A member 4, snoRNP protein DKC1, DKC1, DKC1, DKC1 , DKC1 , DKC, DKC, DKC , DKC , CBF5, CBF5, CBF5 , CBF5 , DKCX, DKCX, DKCX , DKCX , NAP57, NAP57, NAP57 , NAP57 , NOLA4, NOLA4, NOLA4 , NOLA4 , XAP101, XAP101, XAP101 , XAP101 , dyskeratosis congenita 1, dyskerin, dyskeratosis congenita 1, dyskerin, dyskeratosis congenita 1, dyskerin , dyskeratosis congenita 1, dyskerin , H/ACA ribonucleoprotein complex subunit 4, H/ACA ribonucleoprotein complex subunit 4, H/ACA ribonucleoprotein complex subunit 4 , H/ACA ribonucleoprotein complex subunit 4 , CBF5 homolog, CBF5 homolog, CBF5 homolog , CBF5 homolog , Dyskerin, Dyskerin, Dyskerin , Dyskerin , Nopp140-associated protein of 57 kDa, Nopp140-associated protein of 57 kDa, Nopp140-associated protein of |
| Gene, Accession # | DKC1, Gene ID: 1736, UniProt: O60832 |
| Catalog # | abx001537 |
| Price | please inquire |
| Order / More Info | H/ACA Ribonucleoprotein Complex Subunit DKC1 (DKC1) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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