14-3-3 Protein Sigma (SFN) Antibody from ABBEXA LTD
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| Antigenic Specificity | 14-3-3 Protein Sigma (SFN) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 100 µg, |
| Concentration | 2 mg/ml |
| Applications | ELISA, WB, IHC, IF/ICC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | 14-3-3 Protein Sigma (SFN) antibody is a Rabbit polyclonal antibody for the detection of SFN. 14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms, denoted 14-3-3 b, g, e, z, h, q and s, comprise this family of signaling intermediates. 14-3-3 s, also known as SFN, stratifin, HME1 or YWHAS, is a secreted adaptor protein that is involved in regulating both general and specific signaling pathways. Expressed predominately in stratified squamous keratinising epithelium, 14-3-3 s is able to bind and modify the activity of a large number of proteins, such as KRT17 (Keratin 17), through recognition of a phosphothreonine or phosphoserine motif. When bound to Keratin 17, for example, 14-3-3 s acts to stimulate the Akt/mTOR signaling pathway by upregulating protein synthesis and cell growth. 14-3-3 s also functions to positively mediate IGF-I-induced cell cycle progression and can bind to a variety of translation initiation factors, thus controlling mitotic translation. In response to tumor growth, 14-3-3 s positively regulates the tumor suppressor p53 and increases the rate of p53-regulated inhibition of G2/M cell cycle progression. Multiple isoforms of 14-3-3 s exist due to alternative splicing events. |
| Immunogen | 14-3-3 protein sigma |
| Other Names | SFN, Stratifin, Epithelial Cell Marker Protein 1, 14-3-3 Sigma, 14-3-3 Protein Sigma, YWHAS, HME1, SFN, SFN, SFN , SFN , Stratifin, Stratifin, Stratifin , Stratifin , Epithelial Cell Marker Protein 1, Epithelial Cell Marker Protein 1, Epithelial Cell Marker Protein 1 , Epithelial Cell Marker Protein 1 , 14-3-3 Sigma, 14-3-3 Sigma, 14-3-3 Sigma , 14-3-3 Sigma , 14-3-3 Protein Sigma, 14-3-3 Protein Sigma, 14-3-3 Protein Sigma , 14-3-3 Protein Sigma , YWHAS, YWHAS, YWHAS , YWHAS , HME1, HME1, HME1 , HME1 |
| Gene, Accession # | SFN, Gene ID: 2810, UniProt: P31947 |
| Catalog # | abx218542 |
| Price | please inquire |
| Order / More Info | 14-3-3 Protein Sigma (SFN) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
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