Checkpoint Kinase 2 (CHEK2) Antibody from ABBEXA LTD
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| Antigenic Specificity | Checkpoint Kinase 2 (CHEK2) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC, IF/ICC, FCM |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CHEK2 is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. |
| Immunogen | KLH-conjugated synthetic peptide between 111-141 amino acids from the N-terminal region of human CHEK2. |
| Other Names | CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, CHEK2, Serine/threonine-protein kinase Chk2, CHK2 checkpoint homolog, Cds1 homolog, Checkpoint kinase 2, hCds1, CDS1, CDS1, CDS1 , CDS1 , CHK2, CHK2, CHK2 , CHK2 , HuCds1, HuCds1, HuCds1 , HuCds1 , LFS2, LFS2, LFS2 , LFS2 , PP1425, PP1425, PP1425 , PP1425 , RAD53, RAD53, RAD53 , RAD53 , CHEK2, CHEK2, CHEK2 , CHEK2 , Serine/threonine-protein kinase Chk2, Serine/threonine-protein kinase Chk2, Serine/threonine-protein kinase Chk2 , Serine/threonine-protein kinase Chk2 , CHK2 checkpoint homolog, CHK2 checkpoint homolog, CHK2 checkpoint homolog , CHK2 checkpoint homolog , Cds1 homolog, Cds1 homolog, Cds1 homolog , Cds1 homolog , Checkpoint kinase 2, Checkpoint kinase 2, Checkpoint kinase 2 , Checkpoint kinase 2 , hCds1, hCds1, hCds1 , hCds1 |
| Gene, Accession # | CHEK2, NCBI: NP_001005735.1, NP_001244316.1, NP_009125.1, NP_665861.1, UniProt: O96017 |
| Catalog # | abx032373 |
| Price | please inquire |
| Order / More Info | Checkpoint Kinase 2 (CHEK2) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
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