Checkpoint Kinase 2 (CHEK2) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-Checkpoint Kinase 2 (CHEK2) antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | Checkpoint Kinase 2 (CHEK2) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 20 µl, 50 µl, 100 µl, 200 µl |
| Concentration | > 0.5 mg/ml |
| Applications | WB, IF/ICC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CHEK2 antibody is a Rabbit polyclonal antibody against CHEK2. In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. |
| Immunogen | Recombinant protein of human CHEK2. |
| Other Names | CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, CHEK2, Serine/threonine-protein kinase Chk2, CHK2 checkpoint homolog, Cds1 homolog, Checkpoint kinase 2, hCds1, CDS1, CDS1, CDS1 , CDS1 , CHK2, CHK2, CHK2 , CHK2 , HuCds1, HuCds1, HuCds1 , HuCds1 , LFS2, LFS2, LFS2 , LFS2 , PP1425, PP1425, PP1425 , PP1425 , RAD53, RAD53, RAD53 , RAD53 , CHEK2, CHEK2, CHEK2 , CHEK2 , Serine/threonine-protein kinase Chk2, Serine/threonine-protein kinase Chk2, Serine/threonine-protein kinase Chk2 , Serine/threonine-protein kinase Chk2 , CHK2 checkpoint homolog, CHK2 checkpoint homolog, CHK2 checkpoint homolog , CHK2 checkpoint homolog , Cds1 homolog, Cds1 homolog, Cds1 homolog , Cds1 homolog , Checkpoint kinase 2, Checkpoint kinase 2, Checkpoint kinase 2 , Checkpoint kinase 2 , hCds1, hCds1, hCds1 , hCds1 |
| Gene, Accession # | CHEK2, Gene ID: 11200, UniProt: O96017 |
| Catalog # | abx001757 |
| Price | please inquire |
| Order / More Info | Checkpoint Kinase 2 (CHEK2) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
ABBEXA LTD
181 Cambridge Science Park
Cambridge, CB4 0GJ UK
P: +44 (0) 1223 755950
Customer Service: info@abbexa.com
Technical Support: support@abbexa.com
Orders: orders@abbexa.com
https://www.abbexa.com
U.S. Office
118 Eldridge Rd, Suite C,
Sugar Land, TX 77478 USA
Telephone: +1 832 327 7413
Netherlands Office
Abbexa BV
Wattstraat 54 2723 RD,
Zoetermeer,Netherlands
Telephone: +44 (0) 1223 755950
Profile of ABBEXA LTD
Return to Antibodies