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Antigenic Specificity | Circadian Locomoter Output Cycles Protein Kaput (CLOCK) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 20 µl, 50 µl, 100 µl, 200 µl |
Concentration | > 0.5 mg/ml |
Applications | WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CLOCK antibody is a Rabbit polyclonal antibody against CLOCK. The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. |
Immunogen | A synthetic peptide of human CLOCK. |
Other Names | BHLHE8, circadian locomoter output cycles kaput protein, Circadian locomoter output cycles protein kaput, Class E basic helix-loop-helix protein 8, CLOCK, clock homolog (mouse), hCLOCK, KAT13D, KIAA0334, circadian locomotor output cycles kaput, BHLHE8, BHLHE8, BHLHE8 , BHLHE8 , circadian locomoter output cycles kaput protein, circadian locomoter output cycles kaput protein, circadian locomoter output cycles kaput protein , circadian locomoter output cycles kaput protein , Circadian locomoter output cycles protein kaput, Circadian locomoter output cycles protein kaput, Circadian locomoter output cycles protein kaput , Circadian locomoter output cycles protein kaput , Class E basic helix-loop-helix protein 8, Class E basic helix-loop-helix protein 8, Class E basic helix-loop-helix protein 8 , Class E basic helix-loop-helix protein 8 , CLOCK, CLOCK, CLOCK , CLOCK , clock homolog (mouse), clock homolog (mouse), clock homolog (mouse) , clock homolog (mouse) , hCLOCK, hCLOCK, hCLOCK , |
Gene, Accession # | CLOCK, Gene ID: 9575, UniProt: O15516 |
Catalog # | abx004307 |
Price | please inquire |
Order / More Info | Circadian Locomoter Output Cycles Protein Kaput (CLOCK) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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