Mouse TSC2 (pS1412) Antibody from ABBEXA LTD
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| Antigenic Specificity | Mouse TSC2 (pS1412) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, DB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). Specifically stimulates the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. Suggesting a possible mechanism for its role in regulating cellular growth (By similarity). |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1412 of mouse TSC2. |
| Other Names | Tsc2, Tuberin, Tuberous sclerosis 2 protein homolog, Tsc2, Tsc2, Tsc2 , Tsc2 , Tuberin, Tuberin, Tuberin , Tuberin , Tuberous sclerosis 2 protein homolog, Tuberous sclerosis 2 protein homolog, Tuberous sclerosis 2 protein homolog , Tuberous sclerosis 2 protein homolog |
| Gene, Accession # | UniProt: Q61037 |
| Catalog # | abx032234 |
| Price | please inquire |
| Order / More Info | Mouse TSC2 (pS1412) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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