MAP Kinase-Interacting Serine/threonine-Protein Kinase 2 (MNK2) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-MAP Kinase-Interacting Serine/threonine-Protein Kinase 2 (MNK2) antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | MAP Kinase-Interacting Serine/threonine-Protein Kinase 2 (MNK2) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | Protein G purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | MAP kinase-interacting kinase 1 (Mnk1) and Mnk2, members of the Ser/Thr protein kinase family, bind tightly to the growth factor-regulated MAP kinases, Erk1 and Erk2. Erk and p38 phosphorylate MNK1 and Mnk2, which stimulates their in vitro kinase activity toward a substrate, eukaryotic initiation factor-4E (eIF-4E). Overexpression of Mnk2 results in increased phosphorylation of endogenous eIF-4E, showing that it can act as an eIF-4E kinase in vivo. Mnk2 may play a role in the response to environmental stress and cytokines. This ubiquitiously expressed protein appears to regulate transcription by phosphorylating eIF-4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Expression of active mutants of MNK1 and MNK2 in 293 cells diminishes cap-dependent translation relative to cap-independent translation in a transient reporter assay. Human Mnk2 is homologous to murine Mnk2 (approximately 94% identical) and human Mnk1 (71% identical). In vitro phosphorylation studies show that Mnk2 is a significantly better substrate than Mnk1 for extracellular signal-regulated kinase 2 (Erk2), p38MAPKalpha, and p38MAPKbeta. Mnk2 has also been shown to interact with the C-terminal regions of eIF-4G1 and eIF-4G2. |
| Immunogen | KLH-conjugated synthetic peptide between 70-100 amino acids from the N-terminal region of human MNK2 (MKNK2). |
| Other Names | MKNK2, GPRK7, MNK2, MAP kinase-interacting serine/threonine-protein kinase 2, MAP kinase signal-integrating kinase 2, MKNK2, MKNK2, MKNK2 , MKNK2 , GPRK7, GPRK7, GPRK7 , GPRK7 , MNK2, MNK2, MNK2 , MNK2 , MAP kinase-interacting serine/threonine-protein kinase 2, MAP kinase-interacting serine/threonine-protein kinase 2, MAP kinase-interacting serine/threonine-protein kinase 2 , MAP kinase-interacting serine/threonine-protein kinase 2 , MAP kinase signal-integrating kinase 2, MAP kinase signal-integrating kinase 2, MAP kinase signal-integrating kinase 2 , MAP kinase signal-integrating kinase 2 |
| Gene, Accession # | UniProt: Q9HBH9 |
| Catalog # | abx033149 |
| Price | please inquire |
| Order / More Info | MAP Kinase-Interacting Serine/threonine-Protein Kinase 2 (MNK2) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
ABBEXA LTD
181 Cambridge Science Park
Cambridge, CB4 0GJ UK
P: +44 (0) 1223 755950
Customer Service: info@abbexa.com
Technical Support: support@abbexa.com
Orders: orders@abbexa.com
https://www.abbexa.com
U.S. Office
118 Eldridge Rd, Suite C,
Sugar Land, TX 77478 USA
Telephone: +1 832 327 7413
Netherlands Office
Abbexa BV
Wattstraat 54 2723 RD,
Zoetermeer,Netherlands
Telephone: +44 (0) 1223 755950
Profile of ABBEXA LTD
Return to Antibodies