ITGA2B/ITGB3 (Abciximab biosimilar) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-ITGA2B/ITGB3 (Abciximab biosimilar) antibody, protein, ELISA kits.
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| Antigenic Specificity | ITGA2B/ITGB3 (Abciximab biosimilar) |
| Clone | monoclonal |
| Host Species | Chimeric Human/Mouse |
| Reactive Species | human |
| Isotype | n/a |
| Format | Protein A/G purified |
| Size | 100 µg, 1 mg, |
| Concentration | typically between 0.5-2.0 mg/ml. |
| Applications | ELISA, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Abciximab is a monoclonal antibody biosimilar expressed in CHO cells, targeting ITGA2B/ITGB3, for use in laboratory research applications. This product is not suitable for use as medicines or in human, therapeutic or diagnostic applications. Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (?v?3) receptor found on platelets and vessel wall endothelial and smooth muscle cells. Abciximab binds to the intact platelet GPIIb/IIIa receptor, which is a member of the integrin family of adhesion receptors and the major platelet surface receptor involved in platelet aggregation. This binding is thought to involve steric hindrance and/or conformational alterations which block access of large molecules to the receptor rather than direct interaction with the RGD (arginine-glycine-aspartic acid) binding site of GPIIb/IIIa. By binding to the vitronectin receptor (also known as the ?v?3 integrin), abciximab blocks effects mediated by this integrin which include cell adhesion. Furthermore, abciximab blocks Mac-1 receptor on monocytes and neutrophils thus inhibiting monocyte adhesion. |
| Immunogen | n/a |
| Other Names | Abciximab, ITGA2B/ITGB3, 143653-53-6 |
| Gene, Accession # | CAS: 143653-53-6 |
| Catalog # | abx831060 |
| Price | please inquire |
| Order / More Info | ITGA2B/ITGB3 (Abciximab biosimilar) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
ABBEXA LTD
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