Breast Cancer Type 1 Susceptibility Protein (BRCA1) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-Breast Cancer Type 1 Susceptibility Protein (BRCA1) antibody, protein, ELISA kits.
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| Antigenic Specificity | Breast Cancer Type 1 Susceptibility Protein (BRCA1) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | affinity purified |
| Size | 20 µl, 50 µl, 100 µl, 200 µl |
| Concentration | > 0.5 mg/ml |
| Applications | WB, IHC, IF/ICC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | BRCA1 antibody is a Rabbit polyclonal antibody against BRCA1. This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. |
| Immunogen | A synthetic peptide of human BRCA1. |
| Other Names | aeBRCA1, Breast cancer type 1 susceptibility protein, BRCA1, BRCAI, BRCC1, BROVCA1, IRIS, PSCP, RNF53, familial breast/ovarian cancer gene 1, PNCA4, PPP1R53, Ring Finger Protein 53, aeBRCA1, aeBRCA1, aeBRCA1 , aeBRCA1 , Breast cancer type 1 susceptibility protein, Breast cancer type 1 susceptibility protein, Breast cancer type 1 susceptibility protein , Breast cancer type 1 susceptibility protein , BRCA1, BRCA1, BRCA1 , BRCA1 , BRCAI, BRCAI, BRCAI , BRCAI , BRCC1, BRCC1, BRCC1 , BRCC1 , BROVCA1, BROVCA1, BROVCA1 , BROVCA1 , IRIS, IRIS, IRIS , IRIS , PSCP, PSCP, PSCP , PSCP , RNF53, RNF53, RNF53 , RNF53 , familial breast/ovarian cancer gene 1, familial breast/ovarian cancer gene 1, familial breast/ovarian cancer gene 1 , familial breast/ovarian cancer gene 1 , PNCA4, PNCA4, PNCA4 , PNCA4 , PPP1R53, PPP1R53, PPP1R53 , PPP1R53 , Ring Finger Protein 53, Ring Finger Protein 53, Ring Finger Protein 53 , Ring Finger Protein 53 |
| Gene, Accession # | BRCA1, Gene ID: 672, UniProt: P38398 |
| Catalog # | abx000600 |
| Price | please inquire |
| Order / More Info | Breast Cancer Type 1 Susceptibility Protein (BRCA1) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
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