Edit |   |
---|---|
Antigenic Specificity | MS4A1(CD20, MS4A-1) (Ibritumomab biosimilar) |
Clone | monoclonal |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG2A |
Format | Protein A/G purified |
Size | 100 µg, 1 mg, |
Concentration | typically between 0.5-2.0 mg/ml. |
Applications | ELISA, WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Ibritumomab is a monoclonal antibody biosimilar expressed in CHO cells, targeting MS4A1(CD20, MS4A-1), for use in laboratory research applications. This product is not suitable for use as medicines or in human, therapeutic or diagnostic applications. Ibritumomab is a monoclonal antibody directed against the CD20 antigen found on pre-B and mature B lymphocytes (normal and malignant). Ibritumomab binding induces apoptosis in B lymphocytes in vitro. It is combined with the chelator tiuxetan, which acts as a specific chelation site for Yttrium-90 (Y-90). The monoclonal antibody acts as a delivery system to direct the radioactive isotope to the targeted cells, however, binding has been observed in lymphoid cells throughout the body and in lymphoid nodules in organs such as the large and small intestines. Beta-emission induces cellular damage through the formation of free radicals (in both target cells and surrounding cells). |
Immunogen | n/a |
Other Names | Ibritumomab, MS4A1(CD20,MS4A-1) |
Gene, Accession # | n/a |
Catalog # | abx831581 |
Price | please inquire |
Order / More Info | MS4A1(CD20, MS4A-1) (Ibritumomab biosimilar) Antibody from ABBEXA LTD |
Product Specific References | n/a |
U.S. Office
118 Eldridge Rd, Suite C,
Sugar Land, TX 77478 USA
Telephone: +1 832 327 7413
Netherlands Office
Abbexa BV
Wattstraat 54 2723 RD,
Zoetermeer,Netherlands
Telephone: +44 (0) 1223 755950