ERBB3 (pY1328) Antibody from ABBEXA LTD
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| Antigenic Specificity | ERBB3 (pY1328) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 50 µl, 100 µl, 200 µl, |
| Concentration | > 0.5 mg/ml |
| Applications | WB, IHC, IF/ICC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | ERBB3 (pY1328) antibody is a Rabbit polyclonal antibody against ERBB3 (pY1328). This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. |
| Immunogen | Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding Y1328 of human ERBB3. |
| Other Names | ERB3, ERBB3, HER3, Receptor protein-tyrosine kinase erbB-3 precursor, Tyrosine kinase-type cell surface receptor HER3, c-erbB3, kinase ErbB3, Receptor tyrosine-protein kinase erbB-3, Proto-oncogene-like protein c-ErbB-3, LCCS2, ErbB-3, erbB3-S, MDA-BF-1, c-erbB-3, p180-ErbB3, p45-sErbB3, p85-sErbB3, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian), MGC88033, ERB3, ERB3, ERB3 , ERB3 , ERBB3, ERBB3, ERBB3 , ERBB3 , HER3, HER3, HER3 , HER3 , Receptor protein-tyrosine kinase erbB-3 precursor, Receptor protein-tyrosine kinase erbB-3 precursor, Receptor protein-tyrosine kinase erbB-3 precursor , Receptor protein-tyrosine kinase erbB-3 precursor , Tyrosine kinase-type cell surface receptor HER3, Tyrosine kinase-type cell surface receptor HER3, Tyrosine kinase-type cell surface receptor HER3 , Tyrosine kinase-type cell surface receptor HER3 , c-erbB3, c-erbB3, c-erbB3 , c-erbB3 , kinase ErbB3, kinase ErbB3, kinase ErbB3 , kinase ErbB3 , Receptor tyrosine-protein kinase |
| Gene, Accession # | ERBB3, Gene ID: 2065, UniProt: P21860 |
| Catalog # | abx000328 |
| Price | please inquire |
| Order / More Info | ERBB3 (pY1328) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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