Bad BH3 Domain Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-Bad BH3 Domain antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | Bad BH3 Domain |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | Protein G purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC, FCM |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Apoptosis or programmed cell death is a physiological cellular process characterized by cell shrinkage, membrane blebbing, DNA fragmentation, and release of Cytochrome C from the mitochondria. It is utilized by the organism to get rid of unwanted cells, which is critical for normal development and homeostasis of an organism. Disregulation of normal apoptosis process have been implicated in a variety of diseases, including cancer, autoimmune diseases, viral infections, etc. Programmed cell death occurs through complex cascades of cell signaling in which Bcl-2 family members, among others, play an important role.The Bcl-2 family of proteins regulate apoptosis as well as execute death signals at the mitochondrion. Members of this family include both pro and anti-apoptotic proteins that hare homology sequences called Bcl-2 Homology domains (BH1-4) which mediate dimmer formation. The BH3 proteins, such as BID, NOXA, PUMA, BIK, BIM and BAD are all pro-apoptotic and share sequence homology within the amphipathic alpha-helical BH3 region, which is required for their apoptotic function. They may trigger release of death-inducing molecules such as Cytochrome C, Smac, and endonuclease G. Anti-apoptotic family members, including Bcl-2 and Bcl-XL, play inhibitory roles. Bcl-2 family proteins may form homodimers or heterodimers between pro and anti-apoptotic members, the ratios of which determine the cell fate. |
| Immunogen | KLH-conjugated synthetic peptide between 92-127 amino acids from human Bad BH3 Domain. |
| Other Names | BAD, BBC6, BCL2L8, Bcl2 antagonist of cell death, Bcl-2-binding component 6, Bcl-2-like protein 8, Bcl-XL/Bcl-2-associated death promoter, BAD, BAD , BAD , BAD, BBC6, BBC6 , BBC6 , BBC6, BCL2L8, BCL2L8 , BCL2L8 , BCL2L8, Bcl2 antagonist of cell death, Bcl2 antagonist of cell death , Bcl2 antagonist of cell death , Bcl2 antagonist of cell death, Bcl-2-binding component 6, Bcl-2-binding component 6 , Bcl-2-binding component 6 , Bcl-2-binding component 6, Bcl-2-like protein 8, Bcl-2-like protein 8 , Bcl-2-like protein 8 , Bcl-2-like protein 8, Bcl-XL/Bcl-2-associated death promoter, Bcl-XL/Bcl-2-associated death promoter , Bcl-XL/Bcl-2-associated death promoter , Bcl-XL/Bcl-2-associated death promoter |
| Gene, Accession # | UniProt: Q92934 |
| Catalog # | abx027290 |
| Price | please inquire |
| Order / More Info | Bad BH3 Domain Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
ABBEXA LTD
181 Cambridge Science Park
Cambridge, CB4 0GJ UK
P: +44 (0) 1223 755950
Customer Service: info@abbexa.com
Technical Support: support@abbexa.com
Orders: orders@abbexa.com
https://www.abbexa.com
U.S. Office
118 Eldridge Rd, Suite C,
Sugar Land, TX 77478 USA
Telephone: +1 832 327 7413
Netherlands Office
Abbexa BV
Wattstraat 54 2723 RD,
Zoetermeer,Netherlands
Telephone: +44 (0) 1223 755950
Profile of ABBEXA LTD
Return to Antibodies