Raf Proto-Oncogene Serine/Threonine Protein Kinase (RAF1) Antibody from ABBEXA LTD
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| Antigenic Specificity | Raf Proto-Oncogene Serine/Threonine Protein Kinase (RAF1) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, rat |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 100 µg, |
| Concentration | 2 mg/ml |
| Applications | ELISA, WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Raf Proto-Oncogene Serine/Threonine Protein Kinase (RAF1) antibody is a Rabbit polyclonal antibody for the detection of RAF1. Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. |
| Immunogen | v-raf-1 murine leukemia viral oncogene homolog 1 |
| Other Names | c-RAF, CRAF, kinase Raf1, Protein kinase raf 1, RAF proto-oncogene serine/threonine-protein kinase, RAF-1, RAF1, Similar to murine leukemia viral (V-raf-1) oncogene homolog 1, RAF, Proto-oncogene c-RAF, NS5, s C-RAF, c-RAF, c-RAF, c-RAF , c-RAF , CRAF, CRAF, CRAF , CRAF , kinase Raf1, kinase Raf1, kinase Raf1 , kinase Raf1 , Protein kinase raf 1, Protein kinase raf 1, Protein kinase raf 1 , Protein kinase raf 1 , RAF proto-oncogene serine/threonine-protein kinase, RAF proto-oncogene serine/threonine-protein kinase, RAF proto-oncogene serine/threonine-protein kinase , RAF proto-oncogene serine/threonine-protein kinase , RAF-1, RAF-1, RAF-1 , RAF-1 , RAF1, RAF1, RAF1 , RAF1 , Similar to murine leukemia viral (V-raf-1) oncogene homolog 1, Similar to murine leukemia viral (V-raf-1) oncogene homolog 1, Similar to murine leukemia viral (V-raf-1) oncogene homolog 1 , Similar to murine leukemia viral (V-raf-1) oncogene homolog 1 , RAF, RAF, RAF , RAF , Proto-oncogene c-RAF, Proto-onc |
| Gene, Accession # | RAF1, Gene ID: 5894, UniProt: P04049 |
| Catalog # | abx218161 |
| Price | please inquire |
| Order / More Info | Raf Proto-Oncogene Serine/Threonine Protein Kinase (RAF1) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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