Cyclin Dependent Kinase 5 Activator 1 (CDK5R1) Antibody from ABBEXA LTD
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| Antigenic Specificity | Cyclin Dependent Kinase 5 Activator 1 (CDK5R1) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | Protein G purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | p35 is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5) ; the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. |
| Immunogen | KLH-conjugated synthetic peptide between 272-301 amino acids from the C-terminal region of human CDK5R1 (p35). |
| Other Names | CD5R, CD5R1, CDK5 activator 1, CDK5R, Cyclin-dependent kinase 5 activator 1 precursor, Cyclin-dependent kinase 5 regulatory subunit 1, NCK5A, P23, P25, P35, TPKII regulatory subunit, Tau protein kinase II 23 kDa subunit, CDK5R1, CDK5P35, MGC33831, p35nck5a, Cyclin-dependent kinase 5 activator 1, CD5R, CD5R, CD5R , CD5R , CD5R1, CD5R1, CD5R1 , CD5R1 , CDK5 activator 1, CDK5 activator 1, CDK5 activator 1 , CDK5 activator 1 , CDK5R, CDK5R, CDK5R , CDK5R , Cyclin-dependent kinase 5 activator 1 precursor, Cyclin-dependent kinase 5 activator 1 precursor, Cyclin-dependent kinase 5 activator 1 precursor , Cyclin-dependent kinase 5 activator 1 precursor , Cyclin-dependent kinase 5 regulatory subunit 1, Cyclin-dependent kinase 5 regulatory subunit 1, Cyclin-dependent kinase 5 regulatory subunit 1 , Cyclin-dependent kinase 5 regulatory subunit 1 , NCK5A, NCK5A, NCK5A , NCK5A , P23, P23, P23 , P23 , P25, P25, P25 , P25 , P35, P35, P35 , P35 , TPKII regulatory subunit, TPKII regulatory s |
| Gene, Accession # | UniProt: Q15078 |
| Catalog # | abx033654 |
| Price | please inquire |
| Order / More Info | Cyclin Dependent Kinase 5 Activator 1 (CDK5R1) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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