Growth Factor Receptor Bound Protein 10 (GRB10) Antibody from ABBEXA LTD
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| Antigenic Specificity | Growth Factor Receptor Bound Protein 10 (GRB10) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. |
| Immunogen | KLH-conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human GRB10. |
| Other Names | GRB10, Grb-10, GRBIR, GRB-IR, GRB10 adapter protein, GRB10 adaptor protein, IRBP, Maternally expressed gene 1, MEG1, KIAA0207, RSS, Growth factor receptor-bound protein 10, Insulin receptor-binding protein Grb-IR, GRB10, GRB10, GRB10 , GRB10 , Grb-10, Grb-10, Grb-10 , Grb-10 , GRBIR, GRBIR, GRBIR , GRBIR , GRB-IR, GRB-IR, GRB-IR , GRB-IR , GRB10 adapter protein, GRB10 adapter protein, GRB10 adapter protein , GRB10 adapter protein , GRB10 adaptor protein, GRB10 adaptor protein, GRB10 adaptor protein , GRB10 adaptor protein , IRBP, IRBP, IRBP , IRBP , Maternally expressed gene 1, Maternally expressed gene 1, Maternally expressed gene 1 , Maternally expressed gene 1 , MEG1, MEG1, MEG1 , MEG1 , KIAA0207, KIAA0207, KIAA0207 , KIAA0207 , RSS, RSS, RSS , RSS , Growth factor receptor-bound protein 10, Growth factor receptor-bound protein 10, Growth factor receptor-bound protein 10 , Growth factor receptor-bound protein 10 , Insulin receptor-binding protein Grb-IR, Insulin receptor |
| Gene, Accession # | NCBI: NP_001001549.1, NP_001001550.1, NP_001001555.1, NP_005302.3, UniProt: Q13322 |
| Catalog # | abx034890 |
| Price | please inquire |
| Order / More Info | Growth Factor Receptor Bound Protein 10 (GRB10) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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