Ubiquitin Specific Peptidase 10 (USP10) Antibody from ABBEXA LTD
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| Antigenic Specificity | Ubiquitin Specific Peptidase 10 (USP10) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 100 µg, |
| Concentration | 2 mg/ml |
| Applications | ELISA, IHC, IF/ICC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Ubiquitin Specific Peptidase 10 (USP10) antibody is a Rabbit polyclonal antibody for the detection of USP10. Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). |
| Immunogen | ubiquitin specific peptidase 10 |
| Other Names | Deubiquitinating enzyme 10, KIAA0190, Ubiquitin thiolesterase 10, UBPO, USP10, Deubiquitinating enzyme 10, Deubiquitinating enzyme 10, Deubiquitinating enzyme 10 , Deubiquitinating enzyme 10 , KIAA0190, KIAA0190, KIAA0190 , KIAA0190 , Ubiquitin thiolesterase 10, Ubiquitin thiolesterase 10, Ubiquitin thiolesterase 10 , Ubiquitin thiolesterase 10 , UBPO, UBPO, UBPO , UBPO , USP10, USP10, USP10 , USP10 |
| Gene, Accession # | USP10, Gene ID: 9100, UniProt: Q14694 |
| Catalog # | abx219268 |
| Price | please inquire |
| Order / More Info | Ubiquitin Specific Peptidase 10 (USP10) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
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