Mitogen-Activated Protein Kinase 8/9/10 Phospho-Thr183/Tyr185/Thr221 (MAPK8/9/10 pT183/Y185/T221) Antibody from ABBEXA LTD
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| Antigenic Specificity | Mitogen-Activated Protein Kinase 8/9/10 Phospho-Thr183/Tyr185/Thr221 (MAPK8/9/10 pT183/Y185/T221) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 50 µl, 100 µl, 200 µl, |
| Concentration | > 0.5 mg/ml |
| Applications | WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | MAPK8/9/10 (pT183/Y185/T221) antibody is a Rabbit polyclonal antibody against MAPK8 (pT183/Y185), MAPK9 (pT183/Y185) and MAPK10 (T221). Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells By similarity. Phosphorylates heat shock factor protein 4 (HSF4). /Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. JNK2 isoforms display different binding patterns: a-1 and a-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 a-2, and JUND binds only weakly to it. /Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. Required for stress-induced neuronal apoptosis and the pathogenesis of glutamate excitotoxicity. |
| Immunogen | Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding T183/Y185 of human MAPK8/MAPK9/MAPK10. |
| Other Names | MAPK8, Mitogen-Activated Protein Kinase 8, Stress-Activated Protein Kinase 1c, C-Jun N-Terminal Kinase 1, JUN N-Terminal Kinase, MAP Kinase 8, EC 2.7.11.24, JNK-46, SAPK1c, PRKM8, SAPK1, JNK1, Mitogen-Activated Protein Kinase 8 Isoform JNK1 Alpha1, Mitogen-Activated Protein Kinase 8 Isoform JNK1 Beta2, Stress-Activated Protein Kinase JNK1, Stress-Activated Protein Kinase 1, JNK21B1/2, EC 2.7.11, JNK1A2, MAPK 8, JNK, MAPK8/JNK1, JNK1/MAPK8, JNK-1, JNK 1, MAPK9, Mitogen-Activated Protein Kinase 9, Stress-Activated Protein Kinase JNK2, Stress-Activated Protein Kinase 1a, C-Jun N-Terminal Kinase 2, MAP Kinase 9, EC 2.7.11.24, Jun Kinase 2, MAPK 9, JNK-55, SAPK1a, PRKM9, JNK2, C-Jun Kinase 2, JNK2ALPHA, EC 2.7.11, JNK2BETA, P54aSAPK, JNK2A, JNK2B, SAPK, P54a, MAPK9/JNK2, JNK2/MAPK9, JNK-2, JNK 2, SAPK1, MAPK10, Mitogen-Activated Protein Kinase 10, Stress-Activated Protein Kinase JNK3, Stress-Activated Protein Kinase 1b, C-Jun N-Terminal Kinase 3, MAP Kinase P49 3F12, MAP Kinase 10, EC 2.7.1 |
| Gene, Accession # | MAPK8, MAPK9, MAPK10, Gene ID: 5599/5601/5602, UniProt: P45983, P45984, P53779 |
| Catalog # | abx000327 |
| Price | please inquire |
| Order / More Info | Mitogen-Activated Protein Kinase 8/9/10 Phospho-Thr183/Tyr185/Thr221 (MAPK8/9/10 pT183/Y185/T221) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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