Histone-Lysine N-Methyltransferase SETD7 (SET7) Antibody from ABBEXA LTD
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| Antigenic Specificity | Histone-Lysine N-Methyltransferase SETD7 (SET7) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | Protein G purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Histone methyltransferases (HMTases) selectively methylate evolutionarily conserved arginine or lysine residues, primarily in the N-terminal tails of histones H3 and H4. Signal transduction pathways affecting the N-terminal tails of histones lead to a number of post-translational modifications including acetylation, phosphorylation, poly (ADP-ribosylation), ubiquitination and methylation. These modifications play critical roles in regulating chromatin structure and gene expression. Set7/9 is a histone specific HMTase that methylates histone H3 lysine 4. Set7/9 transfers methyl groups to lysine 4 of histone H3 in complex with S-adenosyl-L-methionine. In yeast, H4-K20 methylation does not have any apparent role in the regulation of gene expression or heterochromatin function; rather it appears to play a role in DNA damage response. Loss of Set9 activity or mutation of H4-K20 markedly impairs yeast cell survival after genotoxic challenge and compromises the ability of cells to maintain checkpoint mediated cell cycle arrest. Genetic experiments link Set9 to Crb2, a homolog of the mammalian checkpoint protein 53BP1, and the enzyme is required for Crb2 localization to sites of DNA damage. |
| Immunogen | KLH-conjugated synthetic peptide between 289-317 amino acids from the C-terminal region of human SET7. |
| Other Names | SETD7, KIAA1717, KMT7, SET7, SET9, Histone-lysine N-methyltransferase SETD7, Histone H3-K4 methyltransferase SETD7, Lysine N-methyltransferase 7, SET domain-containing protein 7, SET7/9, SETD7, SETD7, SETD7 , SETD7 , KIAA1717, KIAA1717, KIAA1717 , KIAA1717 , KMT7, KMT7, KMT7 , KMT7 , SET7, SET7, SET7 , SET7 , SET9, SET9, SET9 , SET9 , Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD7 , Histone-lysine N-methyltransferase SETD7 , Histone H3-K4 methyltransferase SETD7, Histone H3-K4 methyltransferase SETD7, Histone H3-K4 methyltransferase SETD7 , Histone H3-K4 methyltransferase SETD7 , Lysine N-methyltransferase 7, Lysine N-methyltransferase 7, Lysine N-methyltransferase 7 , Lysine N-methyltransferase 7 , SET domain-containing protein 7, SET domain-containing protein 7, SET domain-containing protein 7 , SET domain-containing protein 7 , SET7/9, SET7/9, SET7/9 , SET7/9 |
| Gene, Accession # | UniProt: Q8WTS6 |
| Catalog # | abx026519 |
| Price | please inquire |
| Order / More Info | Histone-Lysine N-Methyltransferase SETD7 (SET7) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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