BRISC And BRCA1-A Complex Member 1 (HSPC142) Antibody from ABBEXA LTD
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| Antigenic Specificity | BRISC And BRCA1-A Complex Member 1 (HSPC142) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | HSPC142 is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. HSPC142 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36. component. |
| Immunogen | KLH-conjugated synthetic peptide between 9-37 amino acids from the N-terminal region of human HSPC142. |
| Other Names | BABAM1, C19orf62, MERIT40, NBA1, BRISC and BRCA1-A complex member 1, Mediator of RAP80 interactions and targeting subunit of 40 kDa, New component of the BRCA1-A complex, BABAM1, BABAM1, BABAM1 , BABAM1 , C19orf62, C19orf62, C19orf62 , C19orf62 , MERIT40, MERIT40, MERIT40 , MERIT40 , NBA1, NBA1, NBA1 , NBA1 , BRISC and BRCA1-A complex member 1, BRISC and BRCA1-A complex member 1, BRISC and BRCA1-A complex member 1 , BRISC and BRCA1-A complex member 1 , Mediator of RAP80 interactions and targeting subunit of 40 kDa, Mediator of RAP80 interactions and targeting subunit of 40 kDa, Mediator of RAP80 interactions and targeting subunit of 40 kDa , Mediator of RAP80 interactions and targeting subunit of 40 kDa , New component of the BRCA1-A complex, New component of the BRCA1-A complex, New component of the BRCA1-A complex , New component of the BRCA1-A complex |
| Gene, Accession # | BABAM1, UniProt: Q9NWV8 |
| Catalog # | abx034003 |
| Price | please inquire |
| Order / More Info | BRISC And BRCA1-A Complex Member 1 (HSPC142) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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