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Antigenic Specificity | KSHV ORF45 |
Clone | monoclonal |
Host Species | Mouse |
Reactive Species | n/a |
Isotype | IgG1 |
Format | ascites |
Size | 100 µl, |
Concentration | n/a |
Applications | ELISA, WB, IHC |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma- (2)-herpesvirus subfamily and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease.The genome of KSHV is 165-170 kb and contains at least 88 open reading frames.ORF45 protein encoded by an immediate-early gene in the KSHV genome is characterized as a phosphorylated protein, and it is localized in the cytoplasm of infected cells.Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7.In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN.Zhu et al (2003) reported that the ORF45 Protein was associated with purified virions. |
Immunogen | Purified recombinant fragment of KSHV ORF45 expressed in E. coli. |
Other Names | ORF45, ORF45, ORF45 , ORF45 , ORF45 |
Gene, Accession # | Gene ID: 4961474 |
Catalog # | abx016034 |
Price | please inquire |
Order / More Info | KSHV ORF45 Antibody from ABBEXA LTD |
Product Specific References | n/a |
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