HDAC4/5/9 (pS246/259/220) Antibody from ABBEXA LTD
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| Antigenic Specificity | HDAC4/5/9 (pS246/259/220) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | affinity purified |
| Size | 50 µl, 100 µl, 200 µl, |
| Concentration | > 0.5 mg/ml |
| Applications | WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | HDAC4/5/9 (pS246/259/220) antibody is a Rabbit polyclonal antibody against HDAC4/5/9 (pS246/259/220). Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional repression. In general,they do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. There are three classes of HDACs; classes 1, 2 and 4, which are closely related Zn2+-dependent enzymes. HDACs are ubiquitously expressed and they can exist in the nucleus or cytosol. Their subcellular localization is effected by protein-protein interactions (for example HDAC-14.3.3 complexes are retained in the cytosol) and by the class to which they belong (class 1 HDACs are predominantly nuclear whilst class 2 HDACs shuttle between the nucleus and cytosol). HDACs have a role in cell growth arrest, differentiation and death and this has led to substantial interest in HDAC inhibitors as possible antineoplastic agents. |
| Immunogen | Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding S246/259/220 of human HDAC4/5/9. |
| Other Names | HD4, AHO3, BDMR, HDACA, HA6116, HDAC-4, HDAC-A/HD5, NY-CO-9/HD7, HD9, HD7b, HDAC, HDRP, MITR, HDAC7, HDAC7B, HDAC9B, HDAC9FL, HD4, HD4, HD4 , HD4 , AHO3, AHO3, AHO3 , AHO3 , BDMR, BDMR, BDMR , BDMR , HDACA, HDACA, HDACA , HDACA , HA6116, HA6116, HA6116 , HA6116 , HDAC-4, HDAC-4, HDAC-4 , HDAC-4 , HDAC-A/HD5, HDAC-A/HD5, HDAC-A/HD5 , HDAC-A/HD5 , NY-CO-9/HD7, NY-CO-9/HD7, NY-CO-9/HD7 , NY-CO-9/HD7 , HD9, HD9, HD9 , HD9 , HD7b, HD7b, HD7b , HD7b , HDAC, HDAC, HDAC , HDAC , HDRP, HDRP, HDRP , HDRP , MITR, MITR, MITR , MITR , HDAC7, HDAC7, HDAC7 , HDAC7 , HDAC7B, HDAC7B, HDAC7B , HDAC7B , HDAC9B, HDAC9B, HDAC9B , HDAC9B , HDAC9FL, HDAC9FL, HDAC9FL , HDAC9FL |
| Gene, Accession # | HDAC4, HDAC5, HDAC9, Gene ID: 9759/10014/9734, UniProt: P56524, Q9UQL6, Q9UKV0 |
| Catalog # | abx000331 |
| Price | please inquire |
| Order / More Info | HDAC4/5/9 (pS246/259/220) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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