PTEN (pY174) Antibody from ABBEXA LTD
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| Antigenic Specificity | PTEN (pY174) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, DB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y174 of human PTEN. |
| Other Names | 10q23del, BZS, DEC, MGC11227, MHAM, MMAC1, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, Mutated in multiple advanced cancers 1, Phosphatase and tensin homolog, Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, PTEN, PTEN1, TEP1, GLM2, Platelet antigen BR, PTEN 1, Tensin homolog, TEP 1, VLA 2 Receptor Alpha Subunit, PTEN (Phospho-Ser370), Phosphatidylinositol 3,4,5-Trisphosphate 3-Phosphatase And Dual-Specificity Protein Phosphatase PTEN, Mitochondrial Phosphatase And Tensin Protein Alpha, Mitochondrial Phosphatase And Tensin Protein , Phosphatase And Tensin-Like Protein, Mitochondrial PTENalpha, Mitochondrial PTEN alpha, Mitochondrial PTEN, Mitochondrial PTEN , CWS1, Phosphatidylinositol 345-Trisphosphate 3-Phosphatase And Dual-Specificity Protein Phosphatase PTEN, Phosphatidylinositol-345-Trisphosphate 3-Phosphatase And Dual-Specificity Protein Phosphatase PTEN, 10q23del, 10q23del, 10q23del , 10q23del , BZS, BZ |
| Gene, Accession # | PTEN, UniProt: P60484 |
| Catalog # | abx032196 |
| Price | please inquire |
| Order / More Info | PTEN (pY174) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
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