Mitogen-Activated Protein Kinase 1 and 3 / ERK1/2 (MAPK1/MAPK3) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-Mitogen-Activated Protein Kinase 1 and 3 / ERK1/2 (MAPK1/MAPK3) antibody, protein, ELISA kits.
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| Antigenic Specificity | Mitogen-Activated Protein Kinase 1 and 3 / ERK1/2 (MAPK1/MAPK3) |
| Clone | monoclonal |
| Host Species | Mouse |
| Reactive Species | human, mouse |
| Isotype | IgG2b |
| Format | ascites |
| Size | 100 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC, FCM |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Mitogen-activated protein kinases (MAPKs) are a widely conserved family of serine/threonine protein kinases involved in many cellular programs such as cell proliferation, differentiation, motility, and death. The p44/42 MAPK (Erk1/2) signaling pathway can be activated in response to a diverse range of extracellular stimuli including mitogens, growth factors, and cytokines and is an important target in the diagnosis and treatment of cancer. Upon stimulation, a sequential three-part protein kinase cascade is initiated, consisting of a MAP kinase kinase kinase (MAPKKK or MAP3K), a MAP kinase kinase (MAPKK or MAP2K), and a MAP kinase (MAPK). Multiple p44/42 MAP3Ks have been identified, including members of the Raf family as well as Mos and Tpl2/Cot. MEK1 and MEK2 are the primary MAPKKs in this pathway. MEK1 and MEK2 activate p44 and p42 through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187, respectively. Several downstream targets of p44/42 have been identified, including p90RSK and the transcription factor Elk-1. p44/42 are negatively regulated by a family of dual-specificity (Thr/Tyr) MAPK phosphatases, known as DUSPs or MKPs, along with MEK inhibitors such as U0126 and PD98059. |
| Immunogen | Purified recombinant fragment of human MAPK expressed in E. Coli. |
| Other Names | ERK, p38, p40, p41, ERK2, ERT1, MAPK2, PRKM1, PRKM2, P42MAPK, p41mapk, MAPK1, ERK, ERK, ERK , ERK , p38, p38, p38 , p38 , p40, p40, p40 , p40 , p41, p41, p41 , p41 , ERK2, ERK2, ERK2 , ERK2 , ERT1, ERT1, ERT1 , ERT1 , MAPK2, MAPK2, MAPK2 , MAPK2 , PRKM1, PRKM1, PRKM1 , PRKM1 , PRKM2, PRKM2, PRKM2 , PRKM2 , P42MAPK, P42MAPK, P42MAPK , P42MAPK , p41mapk, p41mapk, p41mapk , p41mapk , MAPK1, MAPK1, MAPK1 , MAPK1 |
| Gene, Accession # | Gene ID: 5594, UniProt: P27361, P28482 |
| Catalog # | abx011157 |
| Price | please inquire |
| Order / More Info | Mitogen-Activated Protein Kinase 1 and 3 / ERK1/2 (MAPK1/MAPK3) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
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