Polyribonucleotide 5'-Hydroxyl-Kinase Clp1 (CLP1) Antibody from ABBEXA LTD

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Antigenic SpecificityPolyribonucleotide 5'-Hydroxyl-Kinase Clp1 (CLP1)
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
Formatpeptide affinity purified
Size80 µl, 400 µl,
Concentrationn/a
ApplicationsELISA, WB
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DescriptionPolynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.
ImmunogenKLH-conjugated synthetic peptide between 308-336 amino acids from the C-terminal region of human CLP1.
Other NamesCLP1, HEAB, Polynucleotide kinase Clp1, ATP/GTP-binding protein, HClp1, Polyribonucleotide 5'-hydroxyl-kinase Clp1, Pre-mRNA cleavage complex II protein Clp1, CLP1, CLP1, CLP1 , CLP1 , HEAB, HEAB, HEAB , HEAB , Polynucleotide kinase Clp1, Polynucleotide kinase Clp1, Polynucleotide kinase Clp1 , Polynucleotide kinase Clp1 , ATP/GTP-binding protein, ATP/GTP-binding protein, ATP/GTP-binding protein , ATP/GTP-binding protein , HClp1, HClp1, HClp1 , HClp1 , Polyribonucleotide 5'-hydroxyl-kinase Clp1, Polyribonucleotide 5'-hydroxyl-kinase Clp1, Polyribonucleotide 5'-hydroxyl-kinase Clp1 , Polyribonucleotide 5'-hydroxyl-kinase Clp1 , Pre-mRNA cleavage complex II protein Clp1, Pre-mRNA cleavage complex II protein Clp1, Pre-mRNA cleavage complex II protein Clp1 , Pre-mRNA cleavage complex II protein Clp1
Gene, Accession #UniProt: Q92989
Catalog #abx029312
Priceplease inquire
Order / More InfoPolyribonucleotide 5'-Hydroxyl-Kinase Clp1 (CLP1) Antibody from ABBEXA LTD
Product Specific Referencesn/a
ABBEXA LTD
ABBEXA LTD
ABBEXA LTD
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