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Antigenic Specificity | Polyribonucleotide 5'-Hydroxyl-Kinase Clp1 (CLP1) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 80 µl, 400 µl, |
Concentration | n/a |
Applications | ELISA, WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing. |
Immunogen | KLH-conjugated synthetic peptide between 308-336 amino acids from the C-terminal region of human CLP1. |
Other Names | CLP1, HEAB, Polynucleotide kinase Clp1, ATP/GTP-binding protein, HClp1, Polyribonucleotide 5'-hydroxyl-kinase Clp1, Pre-mRNA cleavage complex II protein Clp1, CLP1, CLP1, CLP1 , CLP1 , HEAB, HEAB, HEAB , HEAB , Polynucleotide kinase Clp1, Polynucleotide kinase Clp1, Polynucleotide kinase Clp1 , Polynucleotide kinase Clp1 , ATP/GTP-binding protein, ATP/GTP-binding protein, ATP/GTP-binding protein , ATP/GTP-binding protein , HClp1, HClp1, HClp1 , HClp1 , Polyribonucleotide 5'-hydroxyl-kinase Clp1, Polyribonucleotide 5'-hydroxyl-kinase Clp1, Polyribonucleotide 5'-hydroxyl-kinase Clp1 , Polyribonucleotide 5'-hydroxyl-kinase Clp1 , Pre-mRNA cleavage complex II protein Clp1, Pre-mRNA cleavage complex II protein Clp1, Pre-mRNA cleavage complex II protein Clp1 , Pre-mRNA cleavage complex II protein Clp1 |
Gene, Accession # | UniProt: Q92989 |
Catalog # | abx029312 |
Price | please inquire |
Order / More Info | Polyribonucleotide 5'-Hydroxyl-Kinase Clp1 (CLP1) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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