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Antigenic Specificity | NPC Intracellular Cholesterol Transporter 1 (NPC1) |
Clone | monoclonal |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | Protein G purified |
Size | 100 µl, |
Concentration | 1 mg/ml |
Applications | ELISA, WB, IHC, FCM |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain.It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus.This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol.Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments. |
Immunogen | Purified recombinant fragment of human NPC1 (AA: 34-174) expressed in E. coli. |
Other Names | NPC, Npc1, Niemann Pick type C1, A430089E03Rik, C85354, D18Ertd139e, D18Ertd723e, lcsd, nmf164, spm, niemann-Pick C1 protein, sphingomyelinosis, Niemann-Pick disease, type C1, FLJ98532, NPC, NPC, NPC , NPC , Npc1, Npc1, Npc1 , Npc1 , Niemann Pick type C1, Niemann Pick type C1, Niemann Pick type C1 , Niemann Pick type C1 , A430089E03Rik, A430089E03Rik, A430089E03Rik , A430089E03Rik , C85354, C85354, C85354 , C85354 , D18Ertd139e, D18Ertd139e, D18Ertd139e , D18Ertd139e , D18Ertd723e, D18Ertd723e, D18Ertd723e , D18Ertd723e , lcsd, lcsd, lcsd , lcsd , nmf164, nmf164, nmf164 , nmf164 , spm, spm, spm , spm , niemann-Pick C1 protein, niemann-Pick C1 protein, niemann-Pick C1 protein , niemann-Pick C1 protein , sphingomyelinosis, sphingomyelinosis, sphingomyelinosis , sphingomyelinosis , Niemann-Pick disease, type C1, Niemann-Pick disease, type C1, Niemann-Pick disease, type C1 , Niemann-Pick disease, type C1 , FLJ98532, FLJ98532, FLJ98532 , FLJ98532 |
Gene, Accession # | NPC1, Gene ID: 4864, UniProt: O15118 |
Catalog # | abx015944 |
Price | please inquire |
Order / More Info | NPC Intracellular Cholesterol Transporter 1 (NPC1) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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