Cyclin-Dependent Kinase 4 (CDK4) Antibody from ABBEXA LTD
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| Antigenic Specificity | Cyclin-Dependent Kinase 4 (CDK4) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC, IF/ICC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G (1) /S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G (1) phase. Hypophosphorylates RB1 in early G (1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). |
| Immunogen | KLH-conjugated synthetic peptide between 272-303 amino acids from the C-terminal region of rat Cdk4. |
| Other Names | CDK4, cdk4, CMM3, MGC14458, PSK-J3, Crk3, Cyclin-dependent kinase 4, Cell division protein kinase 4, CDK4, CDK4, CDK4 , CDK4 , cdk4, cdk4, cdk4 , cdk4 , CMM3, CMM3, CMM3 , CMM3 , MGC14458, MGC14458, MGC14458 , MGC14458 , PSK-J3, PSK-J3, PSK-J3 , PSK-J3 , Crk3, Crk3, Crk3 , Crk3 , Cyclin-dependent kinase 4, Cyclin-dependent kinase 4, Cyclin-dependent kinase 4 , Cyclin-dependent kinase 4 , Cell division protein kinase 4, Cell division protein kinase 4, Cell division protein kinase 4 , Cell division protein kinase 4 |
| Gene, Accession # | NCBI: NP_446045.1, UniProt: P35426 |
| Catalog # | abx034947 |
| Price | please inquire |
| Order / More Info | Cyclin-Dependent Kinase 4 (CDK4) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
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