Edit |   |
---|---|
Antigenic Specificity | Fibroblast Growth Factor Receptor 4 (FGFR4) |
Clone | monoclonal |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | ascites |
Size | 100 µl, |
Concentration | n/a |
Applications | ELISA, WB, IHC |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. |
Immunogen | Purified recombinant fragment of FGFR4 expressed in E. Coli. |
Other Names | FGFR-4, CD334 antigen, FGFR4, JTK2, TKF, Fibroblast growth factor receptor 4, CD334, FGFR-4, FGFR-4, FGFR-4 , FGFR-4 , CD334 antigen, CD334 antigen, CD334 antigen , CD334 antigen , FGFR4, FGFR4, FGFR4 , FGFR4 , JTK2, JTK2, JTK2 , JTK2 , TKF, TKF, TKF , TKF , Fibroblast growth factor receptor 4, Fibroblast growth factor receptor 4, Fibroblast growth factor receptor 4 , Fibroblast growth factor receptor 4 , CD334, CD334, CD334 , CD334 |
Gene, Accession # | FGFR4, Gene ID: 2264, UniProt: P22455 |
Catalog # | abx011770 |
Price | please inquire |
Order / More Info | Fibroblast Growth Factor Receptor 4 (FGFR4) Antibody from ABBEXA LTD |
Product Specific References | n/a |
U.S. Office
118 Eldridge Rd, Suite C,
Sugar Land, TX 77478 USA
Telephone: +1 832 327 7413
Netherlands Office
Abbexa BV
Wattstraat 54 2723 RD,
Zoetermeer,Netherlands
Telephone: +44 (0) 1223 755950