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Antigenic Specificity | Cardiotrophin Like Cytokine Factor 1 (CLCF1) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 80 µl, 400 µl, |
Concentration | n/a |
Applications | ELISA, WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This gene is a member of the glycoprotein (gp) 130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
Immunogen | KLH-conjugated synthetic peptide between 46-72 amino acids from the N-terminal region of human CLCF1. |
Other Names | CLCF1, BSF3, CLC, NNT1, Cardiotrophin-like cytokine factor 1, B-cell-stimulating factor 3, Novel neurotrophin-1, Cardiotrophin Like Cytokine Factor 1, BSF-3, NNT-1, CISS2, NR6, B-Cell Stimulatory Factor 3, Cold-Induced Sweating Syndrome 2, B Cell-Stimulating Factor-3, CLCF1, CLCF1, CLCF1 , CLCF1 , BSF3, BSF3, BSF3 , BSF3 , CLC, CLC, CLC , CLC , NNT1, NNT1, NNT1 , NNT1 , Cardiotrophin-like cytokine factor 1, Cardiotrophin-like cytokine factor 1, Cardiotrophin-like cytokine factor 1 , Cardiotrophin-like cytokine factor 1 , B-cell-stimulating factor 3, B-cell-stimulating factor 3, B-cell-stimulating factor 3 , B-cell-stimulating factor 3 , Novel neurotrophin-1, Novel neurotrophin-1, Novel neurotrophin-1 , Novel neurotrophin-1 , Cardiotrophin Like Cytokine Factor 1, Cardiotrophin Like Cytokine Factor 1, Cardiotrophin Like Cytokine Factor 1 , Cardiotrophin Like Cytokine Factor 1 , BSF-3, BSF-3, BSF-3 , BSF-3 , NNT-1, NNT-1, NNT-1 , NNT-1 , CISS2, CISS2, CISS2 , CISS2 , NR6, NR6, |
Gene, Accession # | CLCF1, UniProt: Q9UBD9 |
Catalog # | abx030553 |
Price | please inquire |
Order / More Info | Cardiotrophin Like Cytokine Factor 1 (CLCF1) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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