Ribosomal Protein S6 Kinase A4 (RPS6KA4) Antibody from ABBEXA LTD
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| Antigenic Specificity | Ribosomal Protein S6 Kinase A4 (RPS6KA4) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen-and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. |
| Immunogen | KLH-conjugated synthetic peptide between 481-508 amino acids from the Central region of human RPS6KA4. |
| Other Names | Ribosomal protein S6 kinase alpha-4, 90 kDa ribosomal protein S6 kinase 4, Nuclear mitogen- and stress-activated protein kinase 2, Ribosomal protein kinas, RPS6KA4, MSK2, Nuclear mitogen and stress-activated protein kinase 2, Ribosomal protein kinase B, rps6ka4-, Ribosomal protein S6 kinase alpha-4, Ribosomal protein S6 kinase alpha-4, Ribosomal protein S6 kinase alpha-4 , Ribosomal protein S6 kinase alpha-4 , 90 kDa ribosomal protein S6 kinase 4, 90 kDa ribosomal protein S6 kinase 4, 90 kDa ribosomal protein S6 kinase 4 , 90 kDa ribosomal protein S6 kinase 4 , Nuclear mitogen- and stress-activated protein kinase 2, Nuclear mitogen- and stress-activated protein kinase 2, Nuclear mitogen- and stress-activated protein kinase 2 , Nuclear mitogen- and stress-activated protein kinase 2 , Ribosomal protein kinas, Ribosomal protein kinas, Ribosomal protein kinas , Ribosomal protein kinas , RPS6KA4, RPS6KA4, RPS6KA4 , RPS6KA4 , MSK2, MSK2, MSK2 , MSK2 , Nuclear mitogen and stress-activat |
| Gene, Accession # | UniProt: O75676 |
| Catalog # | abx034700 |
| Price | please inquire |
| Order / More Info | Ribosomal Protein S6 Kinase A4 (RPS6KA4) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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