Mouse Lats2 Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-Mouse Lats2 antibody, protein, ELISA kits.
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| Antigenic Specificity | Mouse Lats2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor (By similarity). |
| Immunogen | KLH-conjugated synthetic peptide between 1000-1027 amino acids from the C-terminal region of mouse Lats2. |
| Other Names | Lats2, Serine/threonine-protein kinase LATS2, Kinase phosphorylated during mitosis protein, Large tumor suppressor homolog 2, Serine/threonine-protein kinase kpm, Lats2, Lats2, Lats2 , Lats2 , Serine/threonine-protein kinase LATS2, Serine/threonine-protein kinase LATS2, Serine/threonine-protein kinase LATS2 , Serine/threonine-protein kinase LATS2 , Kinase phosphorylated during mitosis protein, Kinase phosphorylated during mitosis protein, Kinase phosphorylated during mitosis protein , Kinase phosphorylated during mitosis protein , Large tumor suppressor homolog 2, Large tumor suppressor homolog 2, Large tumor suppressor homolog 2 , Large tumor suppressor homolog 2 , Serine/threonine-protein kinase kpm, Serine/threonine-protein kinase kpm, Serine/threonine-protein kinase kpm , Serine/threonine-protein kinase kpm |
| Gene, Accession # | UniProt: Q7TSJ6 |
| Catalog # | abx031008 |
| Price | please inquire |
| Order / More Info | Mouse Lats2 Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
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