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Antigenic Specificity | COP9 Signalosome Subunit 7A (COPS7A) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 80 µl, 400 µl, |
Concentration | n/a |
Applications | ELISA, WB, IHC |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. |
Immunogen | KLH-conjugated synthetic peptide between 237-266 amino acids from the C-terminal region of human COPS7A. |
Other Names | COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis), COPS7A, CSN7A, MGC110877, COP9 complex subunit 7a, DERP10, SGN7a, Signalosome subunit 7a, COP9 signalosome complex subunit 7a, Dermal papilla-derived protein 10, JAB1-containing signalosome subunit 7a, COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis), COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis), COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis) , COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis) , COPS7A, COPS7A, COPS7A , COPS7A , CSN7A, CSN7A, CSN7A , CSN7A , MGC110877, MGC110877, MGC110877 , MGC110877 , COP9 complex subunit 7a, COP9 complex subunit 7a, COP9 complex subunit 7a , COP9 complex subunit 7a , DERP10, DERP10, DERP10 , DERP10 , SGN7a, SGN7a, SGN7a , SGN7a , Signalosome subunit 7a, Signalosome subunit 7a, Signalosome subunit 7a , Signalosome subunit 7a , COP9 signalosome complex subunit 7a, COP9 signalosome complex subuni |
Gene, Accession # | COPS7A, UniProt: Q9UBW8 |
Catalog # | abx027027 |
Price | please inquire |
Order / More Info | COP9 Signalosome Subunit 7A (COPS7A) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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