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Antigenic Specificity | Centaurin-Gamma-1 (CENTG1) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 80 µl, 400 µl, |
Concentration | n/a |
Applications | ELISA, WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1) dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. |
Immunogen | KLH-conjugated synthetic peptide between 850-877 amino acids from the C-terminal region of human CENTG1. |
Other Names | AGAP2, CENTG1, KIAA0167, Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2, Centaurin-gamma-1, GTP-binding and GTPase-activating protein 2, Phosphatidylinositol 3-kinase enhancer, AGAP2, AGAP2, AGAP2 , AGAP2 , CENTG1, CENTG1, CENTG1 , CENTG1 , KIAA0167, KIAA0167, KIAA0167 , KIAA0167 , Arf-GAP with GTPase, Arf-GAP with GTPase, Arf-GAP with GTPase , Arf-GAP with GTPase , ANK repeat and PH domain-containing protein 2, ANK repeat and PH domain-containing protein 2, ANK repeat and PH domain-containing protein 2 , ANK repeat and PH domain-containing protein 2 , Centaurin-gamma-1, Centaurin-gamma-1, Centaurin-gamma-1 , Centaurin-gamma-1 , GTP-binding and GTPase-activating protein 2, GTP-binding and GTPase-activating protein 2, GTP-binding and GTPase-activating protein 2 , GTP-binding and GTPase-activating protein 2 , Phosphatidylinositol 3-kinase enhancer, Phosphatidylinositol 3-kinase enhancer, Phosphatidylinositol 3-kinase enhancer , Phosphatidylinositol 3-kinase en |
Gene, Accession # | AGAP2, UniProt: Q99490 |
Catalog # | abx026003 |
Price | please inquire |
Order / More Info | Centaurin-Gamma-1 (CENTG1) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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