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Antigenic Specificity | Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta / IKKB (IKBKB) |
Clone | monoclonal |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | ascites |
Size | 100 µl, |
Concentration | n/a |
Applications | ELISA, WB, IHC |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | IKBKB (Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, also called IKK2/IKKB), is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP.Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination.IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta.Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1.Once activated, IKK-beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response.Additionally, IKK-beta activity can also be regulated by MEKK-1. |
Immunogen | Purified recombinant fragment of IKBKB expressed in E. coli. |
Other Names | IKBKB, Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta, IKK-Beta, NFKBIKB, IKK2, IKKB, Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells, Kinase Beta, Inhibitor Of Nuclear Factor Kappa-B Kinase Subunit Beta, Nuclear Factor NF-Kappa-B Inhibitor Kinase Beta, Serine/Threonine Protein Kinase IKBKB, I-Kappa-B-Kinase Beta, I-Kappa-B Kinase, EC 2.7.11.10, Nuclear Factor Kappa B Kinase Subunit Beta, EC 2.7.11.1, EC 2.7.11, IMD15A, IMD15B, IMD15, IKK-B, IKBKB, IKBKB, IKBKB , IKBKB , Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta, Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta, Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta , Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta , IKK-Beta, IKK-Beta, IKK-Beta , IKK-Beta , NFKBIKB, NFKBIKB, NFKBIKB , NFKBIKB , IKK2, IKK2, IKK2 , IKK2 , IKKB, IKKB, IKKB , IKKB , Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells, Kinase Beta, Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B- |
Gene, Accession # | IKBKB, Gene ID: 3551, UniProt: O14920 |
Catalog # | abx016029 |
Price | please inquire |
Order / More Info | Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta / IKKB (IKBKB) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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