Toll-Interacting Protein (TOLLIP) Antibody from ABBEXA LTD
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| Antigenic Specificity | Toll-Interacting Protein (TOLLIP) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | Protein G purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Toll like protein is a component of the signaling pathway of IL1 and Toll like receptors. It inhibits cell activation by microbial products. Tollip recruits IRAK1 to the IL1 receptor complex and inhibits IRAK1 phosphorylation and kinase activity. It oligomerizes and binds to TLR2 and the TLR4-MD2 complex via its C terminus. It exists as a complex with IRAK1 in unstimulated cells. Upon IL1 signaling, Tollip binds to the activated IL1 receptor complex containing IL-1RI, IL-1RacP and the adapter protein MyD88, where it interacts with the TIR domain of IL-1RacP. MyD88 then triggers IRAK1 autophosphorylation, which in turn leads to the dissociation of IRAK1 from Tollip and IL-1RAcP. TOLLIP also interacts with TLR2 and TLR4; TOLLIP overexpression inhibits nuclear factor kappa-B (NFKB) activation in response to lipopolysaccharide and IL1B. |
| Immunogen | KLH-conjugated synthetic peptide between 221-250 amino acids from the C-terminal region of human TOLLIP. |
| Other Names | adapter protein, FLJ33531, IL-1RAcPIP, TOLIP, toll interacting protein, Toll-interacting protein, TOLLIP, Toll Interacting Protein (TOLLIP) C-terminal, C-Term, RABBIT ANTI TOLLIP, adapter protein, adapter protein, adapter protein , adapter protein , FLJ33531, FLJ33531, FLJ33531 , FLJ33531 , IL-1RAcPIP, IL-1RAcPIP, IL-1RAcPIP , IL-1RAcPIP , TOLIP, TOLIP, TOLIP , TOLIP , toll interacting protein, toll interacting protein, toll interacting protein , toll interacting protein , Toll-interacting protein, Toll-interacting protein, Toll-interacting protein , Toll-interacting protein , TOLLIP, TOLLIP, TOLLIP , TOLLIP , Toll Interacting Protein (TOLLIP) C-terminal, Toll Interacting Protein (TOLLIP) C-terminal, Toll Interacting Protein (TOLLIP) C-terminal , Toll Interacting Protein (TOLLIP) C-terminal , C-Term, C-Term, C-Term , C-Term , RABBIT ANTI TOLLIP, RABBIT ANTI TOLLIP, RABBIT ANTI TOLLIP , RABBIT ANTI TOLLIP |
| Gene, Accession # | NCBI: NP_061882.2, UniProt: Q9H0E2 |
| Catalog # | abx031560 |
| Price | please inquire |
| Order / More Info | Toll-Interacting Protein (TOLLIP) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
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