Serine/threonine-Protein Kinase B-Raf (BRAF) Antibody from ABBEXA LTD
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| Antigenic Specificity | Serine/threonine-Protein Kinase B-Raf (BRAF) |
| Clone | monoclonal |
| Host Species | Mouse |
| Reactive Species | human, mouse |
| Isotype | IgG1 |
| Format | ascites |
| Size | 100 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC, IF/ICC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | BRAF: v-raf murine sarcoma viral oncogene homolog B1, also known as BRAF1; RAFB1; B-RAF1; FLJ95109.Entrez Protein NP_004324.It is the main effectors recruited by GTP-bound Ras to activate the MEK-MAP kinase pathway.B-Raf contains three consensus Akt phosphorylationsites (Ser364, Ser428, and Thr439).B-Raf is a key regulatory molecule of the mitogen-activated protein kinase kinase (MEK), it has a long amino-terminal region,the region is essential for homo-dimerization of B-Raf and hetero-dimerization of B-Raf and c-Raf at the plasma membrane, followed by phosphorylation of Thr118 in the amino-terminal B-Raf-specific region.Notably, in calcium ionophore-stimulated HeLa cells, B-Raf could propagate signals to MEK under the basal level of GTP-Ras.Expression of Raf-B is highly restricted with highestlevels in the cerebrum and testes and defects in braf are involved in a wide range of cancers.The BRAF gene mutation is frequently detected in papillary thyroid carcinoma,melanocytic nevi, primary cutaneous melanomas and colorectal cancers. |
| Immunogen | Purified recombinant fragment of human BRAF expressed in E. coli. |
| Other Names | BRAF, B-RAF, B-RAF proto-oncogene serine/threonine-protein kinase, BRAF1, RAFB1, RMIL, RMIL serine/threonine-protein kinase, c-RMIL, kinase B-Raf, p94, v-Raf murine sarcoma viral oncogene homolog B1, Serine/threonine-protein kinase B-raf, Proto-oncogene B-Raf, B-RAF1, FLJ95109, NS7, BRAF, BRAF, BRAF , BRAF , B-RAF, B-RAF, B-RAF , B-RAF , B-RAF proto-oncogene serine/threonine-protein kinase, B-RAF proto-oncogene serine/threonine-protein kinase, B-RAF proto-oncogene serine/threonine-protein kinase , B-RAF proto-oncogene serine/threonine-protein kinase , BRAF1, BRAF1, BRAF1 , BRAF1 , RAFB1, RAFB1, RAFB1 , RAFB1 , RMIL, RMIL, RMIL , RMIL , RMIL serine/threonine-protein kinase, RMIL serine/threonine-protein kinase, RMIL serine/threonine-protein kinase , RMIL serine/threonine-protein kinase , c-RMIL, c-RMIL, c-RMIL , c-RMIL , kinase B-Raf, kinase B-Raf, kinase B-Raf , kinase B-Raf , p94, p94, p94 , p94 , v-Raf murine sarcoma viral oncogene homolog B1, v-Raf murine sarcoma viral on |
| Gene, Accession # | Gene ID: 673 |
| Catalog # | abx015780 |
| Price | please inquire |
| Order / More Info | Serine/threonine-Protein Kinase B-Raf (BRAF) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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