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Antigenic Specificity | Alpha Actinin 4 (ACTN4) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | purified |
Size | 80 µl, 400 µl, |
Concentration | n/a |
Applications | ELISA, WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This protein is a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and is thought to be involved in metastatic processes. Mutations in the gene encoding this protein have been associated with focal and segmental glomerulosclerosis. |
Immunogen | KLH-conjugated synthetic peptide between 192-220 amino acids from the N-terminal region of human ACTN4. |
Other Names | ACTN4, ACTININ-4, Actinin, alpha 4, Actinin alpha4 isoform, FSGS1, F-actin cross-linking protein, Non-muscle alpha-actinin 4, Alpha-actinin-4, FSGS, ACTN4, ACTN4, ACTN4 , ACTN4 , ACTININ-4, ACTININ-4, ACTININ-4 , ACTININ-4 , Actinin, Actinin, Actinin , Actinin , alpha 4, alpha 4, alpha 4 , alpha 4 , Actinin alpha4 isoform, Actinin alpha4 isoform, Actinin alpha4 isoform , Actinin alpha4 isoform , FSGS1, FSGS1, FSGS1 , FSGS1 , F-actin cross-linking protein, F-actin cross-linking protein, F-actin cross-linking protein , F-actin cross-linking protein , Non-muscle alpha-actinin 4, Non-muscle alpha-actinin 4, Non-muscle alpha-actinin 4 , Non-muscle alpha-actinin 4 , Alpha-actinin-4, Alpha-actinin-4, Alpha-actinin-4 , Alpha-actinin-4 , FSGS, FSGS, FSGS , FSGS |
Gene, Accession # | ACTN4, UniProt: O43707 |
Catalog # | abx033682 |
Price | please inquire |
Order / More Info | Alpha Actinin 4 (ACTN4) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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