MAP4K1 (pS171) Antibody from ABBEXA LTD
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| Antigenic Specificity | MAP4K1 (pS171) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The c-Jun amino-terminal kinases (JNKs) /stress-activated protein kinases (SAPKs) play a crucial role in stress responses in mammalian cells. The mechanism underlying this pathway in the hematopoietic system is unclear, but it is a key in understanding the molecular basis of blood cell differentiation. We have cloned a novel protein kinase, termed hematopoietic progenitor kinase 1 (HPK1), that is expressed predominantly in hematopoietic cells, including early progenitor cells. HPK1 is related distantly to the p21 (Cdc42/Rac1) activated kinase (PAK) and yeast STE20 implicated in the mitogen-activated protein kinase (MAPK) cascade. Expression of HPK1 activates JNK1 specifically, and it elevates strongly AP-1-mediated transcriptional activity in vivo. HPK1 binds and phosphorylates MEKK1 directly, whereas JNK1 activation by HPK1 is inhibited by a dominant-negative MEKK1 or MKK4/SEK mutant. Interestingly, unlike PAK65, HPK1 does not contain the small GTPase Rac1/Cdc42-binding domain and does not bind to either Rac1 or Cdc42, suggesting that HPK1. activation is Rac1/Cdc42-independent. These results indicate that HPK1 is a novel functional activator of the JNK/SAPK signaling pathway. |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S171 of human MAP4K1. |
| Other Names | MAP4K1, HPK1, Mitogen-activated protein kinase kinase kinase kinase 1, Hematopoietic progenitor kinase, MAPK/ERK kinase kinase kinase 1, hematopoietic progenitor kinase 1, MAP4K1, MAP4K1, MAP4K1 , MAP4K1 , HPK1, HPK1, HPK1 , HPK1 , Mitogen-activated protein kinase kinase kinase kinase 1, Mitogen-activated protein kinase kinase kinase kinase 1, Mitogen-activated protein kinase kinase kinase kinase 1 , Mitogen-activated protein kinase kinase kinase kinase 1 , Hematopoietic progenitor kinase, Hematopoietic progenitor kinase, Hematopoietic progenitor kinase , Hematopoietic progenitor kinase , MAPK/ERK kinase kinase kinase 1, MAPK/ERK kinase kinase kinase 1, MAPK/ERK kinase kinase kinase 1 , MAPK/ERK kinase kinase kinase 1 , hematopoietic progenitor kinase 1, hematopoietic progenitor kinase 1, hematopoietic progenitor kinase 1 , hematopoietic progenitor kinase 1 |
| Gene, Accession # | UniProt: Q92918 |
| Catalog # | abx031990 |
| Price | please inquire |
| Order / More Info | MAP4K1 (pS171) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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