Thymine DNA Glycosylase (TDG) Antibody from ABBEXA LTD
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| Antigenic Specificity | Thymine DNA Glycosylase (TDG) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 20 µl, 50 µl, 100 µl, 200 µl |
| Concentration | > 0.5 mg/ml |
| Applications | WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | TDG antibody is a Rabbit polyclonal antibody against TDG. In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. G/T mismatch-specific Thymine DNA Glycosylase (TDG) is a nuclear protein which corrects G/T mismatches to G/C pairs by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired thymine. TDG also corrects a subset of G/U mispairs inefficiently removed by the more abundant uracil glycosylases. Retinoic acid receptors interact physically and functionally with TDG, enhancing the ability of the retinoid X receptor and the retinoid X receptor/retinoid acid receptor complex to bind to their response elements. TDG interacts with, and is covalently modified by, the ubiquitin-like proteins SUMO-1 and SUMO-2/3, resulting in a reduction of the DNA substrate and AP site binding affinity of TDG. This sumoylation is associated with a significant increase in enzymatic turnover in reactions with a G/U substrate and the loss of G/T processing activity. |
| Immunogen | Recombinant fusion protein of human TDG. |
| Other Names | TDG, Thymine DNA Glycosylase, Thymine-DNA Glycosylase, HTDG, G/T Mismatch-Specific Thymine DNA Glycosylase, TDG, TDG, TDG , TDG , Thymine DNA Glycosylase, Thymine DNA Glycosylase, Thymine DNA Glycosylase , Thymine DNA Glycosylase , Thymine-DNA Glycosylase, Thymine-DNA Glycosylase, Thymine-DNA Glycosylase , Thymine-DNA Glycosylase , HTDG, HTDG, HTDG , HTDG , G/T Mismatch-Specific Thymine DNA Glycosylase, G/T Mismatch-Specific Thymine DNA Glycosylase, G/T Mismatch-Specific Thymine DNA Glycosylase , G/T Mismatch-Specific Thymine DNA Glycosylase |
| Gene, Accession # | TDG, Gene ID: 6996, UniProt: Q13569 |
| Catalog # | abx001168 |
| Price | please inquire |
| Order / More Info | Thymine DNA Glycosylase (TDG) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
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