Mouse Xaf1 Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-Mouse Xaf1 antibody, protein, ELISA kits.
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| Antigenic Specificity | Mouse Xaf1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Xaf1 seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells (By similarity). |
| Immunogen | KLH-conjugated synthetic peptide between 166-194 amino acids from the Central region of mouse Xaf1. |
| Other Names | Xaf1, Birc4bp, Xiapaf1, XIAP-associated factor 1, BIRC4-binding protein, Xaf1, Xaf1, Xaf1 , Xaf1 , Birc4bp, Birc4bp, Birc4bp , Birc4bp , Xiapaf1, Xiapaf1, Xiapaf1 , Xiapaf1 , XIAP-associated factor 1, XIAP-associated factor 1, XIAP-associated factor 1 , XIAP-associated factor 1 , BIRC4-binding protein, BIRC4-binding protein, BIRC4-binding protein , BIRC4-binding protein |
| Gene, Accession # | UniProt: Q5NBU8 |
| Catalog # | abx030946 |
| Price | please inquire |
| Order / More Info | Mouse Xaf1 Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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