Denticleless Protein Homolog (DTL) Antibody from ABBEXA LTD
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| Antigenic Specificity | Denticleless Protein Homolog (DTL) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, FCM |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX (DTL) complex, also named CRL4 (CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21 (CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21 (CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX (DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX (DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis. |
| Immunogen | KLH-conjugated synthetic peptide between 229-256 amino acids from the Central region of human DTL. |
| Other Names | Denticleless protein homolog, DDB1- and CUL4-associated factor 2, Lethal(2) denticleless protein homolog, Retinoic acid-regulated nuclear matrix-associated protein, DTL, CDT2, CDW1, DCAF2, L2DTL, RAMP, DDB1 and CUL4-associated factor 2, Lethal (2) denticleless protein homolog, Denticleless protein homolog, Denticleless protein homolog, Denticleless protein homolog , Denticleless protein homolog , DDB1- and CUL4-associated factor 2, DDB1- and CUL4-associated factor 2, DDB1- and CUL4-associated factor 2 , DDB1- and CUL4-associated factor 2 , Lethal(2) denticleless protein homolog, Lethal(2) denticleless protein homolog, Lethal(2) denticleless protein homolog , Lethal(2) denticleless protein homolog , Retinoic acid-regulated nuclear matrix-associated protein, Retinoic acid-regulated nuclear matrix-associated protein, Retinoic acid-regulated nuclear matrix-associated protein , Retinoic acid-regulated nuclear matrix-associated protein , DTL, DTL, DTL , DTL , CDT2, CDT2, CDT2 , CDT2 , |
| Gene, Accession # | DTL, UniProt: Q9NZJ0 |
| Catalog # | abx026016 |
| Price | please inquire |
| Order / More Info | Denticleless Protein Homolog (DTL) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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